Recent developments in cognitive science provide compelling leads that need to be interpreted and synthesized within the context of semiotic and biosemiotic principles. To this end, we examine the impact of the mind-body unity on the sorts of choices that an organism is predisposed to making from its Umwelt. In multicellular organisms with brains, the relationship that an organism has with its Umwelt impacts on neural plasticity, the functional specialisations that develop within the brain, and its behaviour. Clinical observations, such (...) as those recorded by Norman Doidge, as well as historical observations from outside the field of semiotics (Plato, Aristotle, Hume) shed further light on this process, and serve to further substantiate our semiotic and biosemiotic paradigm. Our analysis develops a rather limited associationism (with reference to Peirce’s categories) into a more general and robust interpretation that is applicable to all mind-bodies, whether they be neurons, paramecia and amoebae, or humans, cats and dogs. Biosemiotics is a more universal semiotics that takes us beyond the confines of anthropocentrism, because it recognizes the role of the body in shaping Mind. (shrink)