Harold Jeffreys' ideas on the interpretation of probability and epistemology are reviewed. It is argued that with regard to the interpretation of probability, Jeffreys embraces a version of logicism that shares some features of the subjectivism of Ramsey and de Finetti. Jeffreys also developed a probabilistic epistemology, characterized by a pragmatical and constructivist attitude towards notions such as ‘objectivity’, ‘reality’ and ‘causality’. 1 Introductory remarks 2 The interpretation of probability 3 Jeffreys' probabilistic epistemology.