Edgar Zilsel's famous thesis, which argues that modern experimental science was born from the union of artisans and intellectuals in the 16th century, received little support when Zilsel proposed it in the 1940s. In recent years, however, with the turn toward social and cultural history of science, the “Zilsel Thesis” has undergone something of a revival as historians rethink the relevance of artisanal knowledge for the history of early modern science. This essay looks at the Zilsel Thesis in a global (...) setting – specifically a colonial Iberian setting – and argues for its relevance in framing natural history, medicine, and the impact of science on everyday life. Using the examples of corn, quina, and cochineal, this essay argues that the agronomic, chemical, and entomological knowledge accumulated over generations of practice by indigenous practitioners was in fact artisanal knowledge that was passed on to European intellectuals in “global trading zones” to become part of the Western scientific patrimony. (shrink)