Based on formal arguments from Zermelo–Fraenkel set theory we develop the environment for explaining and resolving certain fundamental problems in physics. By these formal tools we show that any quantum system defined by an infinite dimensional Hilbert space of states interferes with the spacetime structure M. M and the quantum system both gain additional degrees of freedom, given by models of Zermelo–Fraenkel set theory. In particular, M develops the ground state where classical gravity vanishes. Quantum mechanics distinguishes set-theoretic random forcing (...) such that M and gravitational degrees of freedom are parameterized by extended real line. The large scale smooth geometry compatible with the forcing extensions is one of exotic smoothness structures of \. The amoeba forcing makes the old real line to have Lebesgue measure zero in the extended one. We apply the entire procedure to the cosmological constant problem, especially to discard the zero-modes contributions to the gravitational vacuum density. Moreover, there exists certain exotic smooth \ from which one determines the realistic, agreeing with observation, small value of the vacuum energy density. (shrink)