This article presents an interpretation of Deleuze’s concept of difference-in-itself. I argue that this is best understood as an adption of Duns Scotus’s concept of ultimate difference. After suggesting that the influence of Scotus on Deleuze extends beyond their shared commitment to the univocity of being, I turn to briefly review Deleuze’s notion of absolute difference. I proceed from there to explain Scotus’s accounts of univocity and ultimate difference, throughout noting the many stark parallels with Deleuze. On the basis of (...) this Scotistic reading of Deleuzian difference, I then show how Deleuze’s synthesis of univocal being and difference-in-itself can be uniquely situated within the fourteenth-century Scotistic disputations on the predicability of univocal being to ultimate difference. I conclude with some suggestions on possible further connections between Deleuze and medieval metaphysics which are opened up through this association of Deleuze with Scotus and the Scotistic tradition. (shrink)