This article develops some of the many ways in which Leonardo and Descartes, throughout the prolific period of human valuation from the fifteenth to the seventeenth centuries, seem to have approached and anchored their seminal contributions on the Cartesian body and metaphysical mind. While Leonardo masterfully developed an iterative thinking system of visual design applied to nature and artifacts, Descartes laid the groundwork for methodical critical thinking in dimensions that ironically ranged from dreams to the controlled narrative, from a deceptive (...) body to a rational man. In an interdisciplinary articulation of historical and neurobiological leanings, contemporary concepts of the cognitive emotional brain, led by Damasio as the basis for his conclusions about the "Descartes Error", as well as a torrent of growing evidence that supports high cognitive abilities in associative processes mediated by action/body lead us to a re-evaluation today of the legacies of Leonardo and Descartes, rescuing a scientific mind/brain/body process that underlies the human mastering of a universal technology of discourse that would revolutionize science. (shrink)