We aim to show from a new perspective that Quine’s ontological relativity, based largely on his so-called “proxy-function argument”, falls short of being a rigorously coherent philosophical conception, as it exhibits significant formal defects. This new perspective enables exposing the shortcomings of Quine's position and suggests a possible reformulation of the original position. Moreover, we argue that his ontological relativity is inconsistent with the empirical data associated with some of our best physical theories, such as quantum mechanics. We refer to (...) fundamental concepts of philosophy and the foundations of mathematics in order to clarify our critique of Quine’s position concerning the relation between formalized theories and both what we can know about the real world and how we come to know it. (shrink)