Major depression is associated with a decrease of 1st person visual perspective in autobiographical memory, even after full remission. This study aimed to examine visual perspective in healthy never-depressed subjects presenting with either genetic or psychological vulnerability for depression. Sixty healthy participants performed the Autobiographical Memory Test with an assessment of visual perspective. Genetic vulnerability was defined by the presence of at least one S or LG allele of the polymorphism of the serotonin-transporter-linked promoter region . Psychological vulnerability was defined (...) by high scores of harm avoidance measured by the Temperament and Character Inventory. Life stress exposure, depressive mood, rumination, and familial history of depression were assessed through standardized procedures. Visual perspective for positive memories was independently predicted by both harm avoidance and a gene by environment interaction between the 5-HTTLPR polymorphism and life stress exposure. Visual perspective and vulnerability for depression may share some biological bases. (shrink)

This article presents a theoretical model of the self processes involved in autobiographical memories and proposes competing hypotheses for the role of visual perspective in autobiographical memory retrieval. Autobiographical memories can be retrieved from either the 1st person perspective, in which individuals see the event through their own eyes, or from the 3rd person perspective, in which individuals see themselves and the event from the perspective of an external observer. A growing body of research suggests that the visual perspective from (...) which a memory is retrieved has important implications for a person’s thoughts, feelings, and goals, and is integrally related to a host of self-evaluative processes. We review the relevant research literature, present our theoretical model, and outline directions for future research. (shrink)

A recent meta-analysis by Munafò, Durrant, Lewis, and Flint [Munafò, M. R., Durrant, C., Lewis, G., & Flint, J. . Gene × environment interactions at the serotonin transporter locus. Biological Psychiatry, 65, 211–219] questioned the meaning of studies searching for endophenotypes associated with the serotonin-transporter-linked promoter region polymorphism, including our study on visual perspective during autobiographical memory retrieval. However, the association of 3rd person perspective with vulnerability for depression does not rely only on genetics. External consistency is provided by the (...) influence of the 5-HTTLPR polymorphism on brain regions involved in emotion regulation and autobiographical memory retrieval . Internal consistency is provided by the increased prevalence of 3rd person perspective in both currently and previously depressed patients, as well as in depression-prone individuals. Further studies should examine therapeutic opportunities. (shrink)