This paper explores the phenomenon of vulnerabilisation in relation to the experiences of persons with chronic illnesses. We distinguish a range of kinds of vulnerability, including epistemic vulnerabilities related to epistemic injustices, and describe various interpersonal and institutional processes which can create, exacerbate and intensify those vulnerabilities. The dynamics of vulnerabilisation are related to individual vices and institutional failings, the pervasive pathophobia of many societies and various contingent life-events. We conclude that susceptibility to varieties of vulnerabilisation is ultimately reflective of (...) the fragility that is definitive of the human condition. (shrink)