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  1. Science, politics, ethics and the pandemic.Kenneth Boyd - 2021 - Journal of Medical Ethics 47 (8):529-530.
    That they are ‘following the science’ has become the watchword of many politicians during the present pandemic, especially when imposing or prolonging lockdowns or other liberty-restricting regulations. The scientists who advise politicians however are usually careful to add that the decision what to restrict and when is ultimately a political one. In science, as in medical practice, there is a delicate balance to be maintained between confidence in the best available information, and the necessary caveat that the assumptions and calculations (...)
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  • (1 other version)Exploring the ethics of tuberculosis human challenge models.Abie Rohrig, Josh Morrison, Gavriel Kleinwaks, Jonathan Pugh, Helen McShane & Julian Savulescu - forthcoming - Journal of Medical Ethics.
    We extend recent conversation about the ethics of human challenge trials to tuberculosis (TB). TB challenge studies could accelerate vaccine development, but ethical concerns regarding risks to trial participants and third parties have been a limiting factor. We analyse the expected social value and risks of different challenge models, concluding that if a TB challenge trial has between a 10% and a 50% chance of leading to the authorisation and near-universal delivery of a more effective vaccine 3–5 years earlier, then (...)
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  • The Fragility of Scientific Rigour and Integrity in “Sped up Science”: Research Misconduct, Bias, and Hype and in the COVID-19 Pandemic.W. Lipworth, I. Kerridge, C. Stewart, D. Silva & R. Upshur - 2023 - Journal of Bioethical Inquiry 20 (4):607-616.
    During the early years of the COVID-19 pandemic, preclinical and clinical research were sped up and scaled up in both the public and private sectors and in partnerships between them. This resulted in some extraordinary advances, but it also raised a range of issues regarding the ethics, rigour, and integrity of scientific research, academic publication, and public communication. Many of the failures of scientific rigour and integrity that occurred during the pandemic were exacerbated by the rush to generate, disseminate, and (...)
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  • Do coronavirus vaccine challenge trials have a distinctive generalisability problem?Nir Eyal & Tobias Gerhard - 2022 - Journal of Medical Ethics 48 (9):586-589.
    Notwithstanding the success of conventional field trials for vaccines against COVID-19, human challenge trials that could obtain more information about these and about other vaccines and further strategies against it are about to start in the UK. One critique of COVID-19 HCTs is their distinct paucity of information on crucial population groups. For safety reasons, these HCTs will exclude candidate participants of advanced age or with comorbidities that worsen COVID-19, yet a vaccine should protect such populations. We turn this cliché (...)
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