In this article, I defend a neuro-Yogacara framework that is based on an understanding of allostatic regulation, and organized around the following four philosophical claims: 1) experience is shaped, in deep and pervasive ways, by a person’s history and their ecological and social context; 2) each moment of experience occurs amid an ongoing flow of conscious activity, which reflects the attempt to integrate diverse sensory and cognitive experiences into a subjective awareness of a world; 3) every claim about a specific (...) feature of experience is an abstraction, which only makes sense within the context of a complex and multidimensional experience of a world; and 4) the experience of being a self, in a world, is malleable. (shrink)