This special issue explores the evolving role of assistive technology in health and medicine, with 3 original articles and 5 commentaries. The following introduction provides an overview of the issue’s unifying themes and the articles’ aims and concerns, as well as reflection on some critical points for discussion raised in the commentaries. Assistive technology finds itself at a pivotal point of development and integration into current systems, where sound and innovative ethical guidance is crucial. With this issue we hope to (...) build capacity for realizing the potential of assistive technology—effectively, sustainably, and ethically. (shrink)