Efforts to formalize qualitative accounts of inference to the best explanation (IBE) confront two obstacles: the imprecise nature of such accounts and the unusual logical properties that explanations exhibit, such as contradiction-intolerance and irreflexivity. This paper aims to surmount these challenges by utilising a new, more precise theory that treats explanations as expressions that codify defeasible inferences. To formalise this account, we provide a sequent calculus in which IBE serves as an elimination rule for a connective that exhibits many of (...) the properties associated with the behaviour of the English expression ‘That... best explains why ... ’. We first construct a calculus that encodes these properties at the level of the turnstile, i.e. as a metalinguistic expression for classes of defeasible consequence relations. We then show how this calculus can be conservatively extended over a language that contains a best-explains-why operator. (shrink)