The characteristic sequence of hypergraphs Pn:n<ω associated to a formula φ, introduced in Malliaris [5], is defined by Pn=i≤nφ. We continue the study of characteristic sequences, showing that graph-theoretic techniques, notably Szemerédi’s celebrated regularity lemma, can be naturally applied to the study of model-theoretic complexity via the characteristic sequence. Specifically, we relate classification-theoretic properties of φ and of the Pn to density between components in Szemerédi-regular decompositions of graphs in the characteristic sequence. In addition, we use Szemerédi regularity to calibrate (...) model-theoretic notions of independence by describing the depth of independence of a constellation of sets and showing that certain failures of depth imply Shelah’s strong order property SOP3; this sheds light on the interplay of independence and order in unstable theories. (shrink)