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  1. Blobel and Sabatini’s “Beautiful Idea”: Visual Representations of the Conception and Refinement of the Signal Hypothesis.Michelle Lynne LaBonte - 2017 - Journal of the History of Biology 50 (4):797-833.
    In 1971, Günter Blobel and David Sabatini proposed a novel and quite speculative schematic model to describe how proteins might reach the proper cellular location. According to their proposal, proteins destined to be secreted from the cell contain a “signal” to direct their release. Despite the fact that Blobel and Sabatini presented their signal hypothesis as a “beautiful idea” not grounded in experimental evidence, they received criticism from other scientists who opposed such speculation. Following the publication of the 1971 model, (...)
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  • The molecular vista: current perspectives on molecules and life in the twentieth century.Mathias Grote, Lisa Onaga, Angela N. H. Creager, Soraya de Chadarevian, Daniel Liu, Gina Surita & Sarah E. Tracy - 2021 - History and Philosophy of the Life Sciences 43 (1):1-18.
    This essay considers how scholarly approaches to the development of molecular biology have too often narrowed the historical aperture to genes, overlooking the ways in which other objects and processes contributed to the molecularization of life. From structural and dynamic studies of biomolecules to cellular membranes and organelles to metabolism and nutrition, new work by historians, philosophers, and STS scholars of the life sciences has revitalized older issues, such as the relationship of life to matter, or of physicochemical inquiries to (...)
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  • Philosophy of Cell Biology.William Bechtel & Andrew Bollhagen - 2019 - Stanford Encyclopedia of Philosophy.
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