The potential for jointly using or integrating Western science and indigenous knowledge, especially in such fields as environmental management, is a hotly debated topic nowadays. However, the difficulties involved in such a task are not always fully understood and co-management experiences achieved only partially the expected outcomes. In this contribution, I show how a sound combination of the two bodies of knowledge would be possible only if there is a way to accommodate different interpretations of reality and knowledge criteria. The (...) issue should then be faced at the epistemological level too, discussing the possibility and implications of a genuine epistemic pluralism. With reference, among others, to Feyerabend’s later writings, here I illustrate some possible insights for addressing the matter that a Western perspectivist stance could provide. (shrink)