Coronavirus disease 2019, as an infectious disease, is now prevalent in many countries around the world, which has recently led many governments to home quarantine and impose penalties for violating quarantine. Concerns and stress caused by lockdown and social isolation led to personal and interactive reactions in some families, which are also culturally important to address. This study was administrated to study the psychological well-being and the effect of home quarantine on marital satisfaction and parental burnout from parenting responsibilities during (...) the prevalence of COVID-19 in Iranian parents. A total of 213 parents voluntarily participated in the online survey in the period of February to mid-April 2020 and completed the 5-item index of the well-being of the World Health Organization, the Kansas Marital Satisfaction Scale, and the Parental Burnout Assessment. The results showed that the effect of home quarantine on MS and PB was not significant in parents. The interactive effect of home quarantine and gender was not significant on MS and PB. In addition, the mothers significantly reported higher PB than the fathers, but the fathers had higher scores in MS and psychological well-being. The effect of some demographic factors on the studied variables was also significant. Supportive resources in family-based culture may play an essential role to reduce the negative effects of stressful situations on family interactions. (shrink)