Focusing upon the five books of his early Hermes series, this article argues that Michel Serres furnishes an accomplished, unconventional philosophical account of communication and mediation-a structuralist epistemology designed to comprehend the sciences in their complexity and plurality-that, even decades after its first publication, has significant value for media theory. Two key themes within this pentalogy are highlighted: firstly, its emphasis upon motifs of communication, transport, and circulation, attempting to grasp the scientific field in topological terms, as a kind of (...) networked encyclopaedia; and secondly, its attempt to account for the intricate relationship between the formal and the empirical in all theorization. (shrink)