The chapter undertakes three main tasks. The first is to review, briefly, the history of psychedelics in psychiatry, including the phenomenological and behavioural effects that first led to their being studied for therapeutic purposes. The second is to give an overview of recent research into the safety, efficacy, and therapeutic mechanisms of psychedelic-assisted psychotherapy. The third is to summarize the contributions of each of the chapters collected in this volume and show how they address philosophical issues arising from the new (...) wave of psychedelic psychiatry. The topics of these chapters cluster around three broad themes, in terms of which the volume is organized: ‘Self and Mind’, ‘Science and Psychiatry’, and ‘Ethics and Spirituality’. (shrink)

5-MeO-DMT is a psychedelic substance with a short duration of action and intensive effects. Its therapeutic efficacy and practicality may significantly surpass those of classical psychedelics such as ayahuasca and LSD. -/- This retrospective ethnographic inquiry features a woman in her mid-thirties who witnessed her mother's violent suicide and its bloody aftermath at the age of three. Before and after that, her childhood was characterized by domestic violence and sexual abuse perpetrated by several members of her family and extended family. (...) In her twenties and thirties, she dated a member of the local mafia with the intention of asking him to kill her father, who had been the main perpetrator of the sexual abuse and violence. This plan was eventually not carried out, but it reflected her deep bitterness and wrath. -/- A process initiated in her early thirties involving four 5-MeO-DMT sessions and a few additional sessions with psilocybin and ayahuasca in the course of two years completely resolved her symptoms related to the abuses, to the extent that she could rebuild a functional relationship with her father and feel love and compassion towards him. This outcome, i.e., the complete reversal of her attitude and emotions towards her father, appeared highly unusual. For the last three years, the outcome had remained stable. -/- The article also presents the perspective of a female facilitator of this treatment process. The article contributes to a better understanding of the use of 5-MeO-DMT in severe traumatization as well as exemplifies the possible positive contributions of actors who are not medical professionals in resolving deep collective traumatization in societies. (shrink)

The scientific study of consciousness, also referred to as consciousness science, is a young scientific field devoted to understanding how conscious experiences and the brain relate. It comprises a host of theories, experiments, and analyses that aim to investigate the problem of consciousness empirically, theoretically, and conceptually. This thesis addresses some of the questions that arise in these investigations from a formal and mathematical perspective. These questions concern theories of consciousness, experimental paradigms, methodology, and artificial consciousness. -/- Regarding theories of (...) consciousness, the thesis contributes to the understanding of the mathematical structure that some of the formal theories in the field propose. The work presented here targets the theory of consciousness known as Integrated Information Theory (IIT) and the neuroscientific theory known as Predictive Processing Theory or Free Energy Principle in its Active Inference form (AI-PP). The thesis provides axiomatic definitions of the mathematical structures that constitute these theories, and uses these definitions to address some of the open questions surrounding the theories. For AI-PP, this includes a rigorous derivation of the formula for Active Inference via Free Energy minimisation and a proof of compositionality of Free Energy. For IIT, this includes resolutions of some of the criticisms of IIT's formal scope and applications, but also the identification of new issues that concern the formalism and its derivation. When possible, the definitions are provided in the mathematical framework of category theory. -/- Regarding experiments, the thesis addresses the main paradigm for testing and falsifying theories of consciousness currently applied in the field. This paradigm consists of comparing the conscious experience that a theory predicts with the conscious experience that is inferred from behavioural data or report by use of measures of consciousness. The thesis provides a formal model of this paradigm and shows that under a certain condition—if inference and prediction are independent—, any minimally informative theory of consciousness can always be falsified. This is deeply problematic since the field’s reliance on report or behaviour to infer conscious experiences, in conjunction with the general structure of most contemporary theories of consciousness, implies such independence. This observation provides the exact formal underpinning of the well-known unfolding argument. The thesis analyses the origin of the problem and identifies precisely which changes are required to avoid this problem in future research. The thesis furthermore shows that the problem of falsifying theories of consciousness, and of empirical comparisons of theories of consciousness more generally, follows from a pervasive closure paradigm in consciousness science, that consists of taking a neuroscientific account of the brain as input to a theory of consciousness, so as to explain what consciousness is, without allowing for modifications or adaptations of the neuroscientific account that would accommodate consciousness as part of the brain's functioning. As is shown in the thesis, this paradigm has implications that point to a fundamental need of revision. -/- Regarding methodological and conceptual questions, the thesis contributes to the foundations of structural research in consciousness science. Structural research aims to use mathematical structures or mathematical spaces, instead of verbal descriptions or simple categorisations, to represent conscious experiences scientifically, for example when building theories of consciousness, or when exploring new empirical avenues to measure consciousness. Despite considerable advances in this realm, there was, prior to this thesis, no explicit definition of what a mathematical structure of conscious experience should be; that is, how the attribution of mathematical structure to conscious experiences should be systematically understood. Perhaps the most important contribution of this thesis to the field is to propose such a definition. The definition, a structural concept, extends existing approaches wherever available, and provides a basis for developing a common formal language to study consciousness, bridging developments as far apart as psychophysics and phenomenology. In addition, and independently of this proposal, the thesis offers a critical analysis of which metaphysical premises need to be presumed in structural research, whether the use of particular formal tools (such as structure-preserving mappings or homomorphisms) is justified, and how structural theories of consciousness could otherwise be built in the first place. An attempt to expand the results from consciousness to more general problems in philosophy of science is made in the context of the well-known Newman problem. -/- Regarding the question of artificial consciousness—can AI feel?—, the thesis contributes two results that take the form of no-go theorems, as known from physics. The first no-go theorem shows that if consciousness is relevant for the temporal evolution of a system's states—if it is dynamically relevant—, then contemporary AI systems cannot be conscious. That is because AI systems run on CPUs, GPUs, TPUs or other processors which have been designed and verified to adhere to computational dynamics that systematically preclude or suppress deviations. The second no-go theorem is situated in the context of computational functionalism, a view which posits that consciousness is a computation. The theorem shows that if computational functionalism holds true, consciousness cannot be a Turing computation. Rather, it must be a novel type of computation that has recently been proposed by Geoffrey Hinton, called mortal computation. -/- This thesis is part of a global effort to pioneer a mathematical perspective in consciousness science, now called Mathematical Consciousness Science. The hope behind the research carried out in this PhD is to illustrate the power and usefulness of mathematical approaches in different areas of consciousness science, and in doing so, to lay the foundations for future mathematical work that complements and supports empirical and theoretical work in the further development of this exciting field. (shrink)