Background Financial compensation may be perceived as a catalyst to increase the recruitment and retention of healthy volunteers in clinical trials but also potentially as a form of undue inducement. The ethical guidelines in Tanzania, while helpful, are not clear on what is considered reasonable compensation for healthy volunteers and the extent to which it influences participation. This study aimed to explore research personnels’ perceptions of the ethical aspects of financial compensation to healthy volunteers participating in prevention trials in Tanzania.Methods (...) Qualitative semi-structured interviews were conducted in Tanzania with a purposive sample of 36 research personnel with different project roles ranging from principal investigators (PIs) to study staff on six prevention trials. The interviews were recorded and transcribed verbatim and thematic analysis was performed.Results Most research personnel were physicians (64%) and male (67%) with a mean age of 48 years. Three qualitative themes were identified: ethical justifications for financial compensation, ethical concerns about financial compensation and fair compensation as income. Most Tanzanian research personnel were more aligned with the view that financial compensation is an ethical responsibility in respecting the value of a healthy volunteer’s time and effort, especially for those who face barriers to participation, rather than being a bribe. However, there were those who raised ethical concerns about financial compensation that included perceptions of bribing low-income earners and increased misperceptions of trial activities. Research personnel also indicated that the specific amount of financial compensation has ethical implications. Amounts that were either too much or too little were viewed as unethical, whereas a modest rate was perceived as ethical.Conclusions Paying healthy volunteers is a measure of respect and supported by the national Tanzanian research guidelines. However, a reevaluation of these research ethical guidelines to redefine reasonable, fair and just financial compensation, especially for those who face significant barriers to participation, would continue to respect healthy volunteers and provide regional guidance for researchers within the country. (shrink)