Cognition is both empowered and limited by representations. The matrix lens model explicates tasks that are based on frequency counts, conditional probabilities, and binary contingencies in a general fashion. Based on a structural analysis of such tasks, the model links several problems and semantic domains and provides a new perspective on representational accounts of cognition that recognizes representational isomorphs as opportunities, rather than as problems. The shared structural construct of a 2 × 2 matrix supports a set of generic tasks (...) and semantic mappings that provide a unifying framework for understanding problems and defining scientific measures. Our model's key explanatory mechanism is the adoption of particular perspectives on a 2 × 2 matrix that categorizes the frequency counts of cases by some condition, treatment, risk, or outcome factor. By the selective steps of filtering, framing, and focusing on specific aspects, the measures used in various semantic domains negotiate distinct trade-offs between abstraction and specialization. As a consequence, the transparent communication of such measures must explicate the perspectives encapsulated in their derivation. To demonstrate the explanatory scope of our model, we use it to clarify theoretical debates on biases and facilitation effects in Bayesian reasoning and to integrate the scientific measures from various semantic domains within a unifying framework. A better understanding of problem structures, representational transparency, and the role of perspectives in the scientific process yields both theoretical insights and practical applications. (shrink)