History of science is, we are told, an important subject for study. Its rise in recent years to become a ‘stand alone’ discipline has been mirrored by an expansion of popular history of science texts available in bookstores. Given this, it is perhaps surprising that little attention has been given to how history of science is written. This article attempts to do that through constructing a typology of histories of science based upon a consideration of audiences who read these texts (...) and writers who construct them. It identifies four ideal types of history of science which describe the opposite poles of two continua running from exoteric to esoteric. The article also examines the content of a sample of history of science texts and finds that often these texts, whether esoteric or exoteric, provide only a chronology of events (often incredibly detailed), avoiding discussion or even mention of wider social, economic and political contexts. Such histories serve to reinforce a ‘standard’ account of science as ‘separate’ from the rest of society, an account that is at odds with almost all contemporary sociology of science and science and technology studies. This prompts the question: why should I read histories of science? (shrink)

In this paper I claim that the goal of mapping and sequencing the human genome is not wholly new, but rather is an extension of an older project to map genes, a central aim of genetics since its birth. Thus, the discussion about the value of the HGP should not be posed in global terms of acceptance or rejection, but in terms of how it should be developed. The first section of this paper presents a brief history of the project. (...) The second section distinguishes among four kinds of issues relevant to an evaluation of the HGP: those economic and organizational issues related to the feasibility of the project; the ethical questions arising in the development of the project and the application of the data gathered; the empirical issues relevant to the scientific value of the project; and conceptual issues like reductionism and determinism relevant to understand the nature and scope of the project. In a third section, I analyze in detail whether the HGP and, more generally, molecular biology is reductionistic. (shrink)

Fred Sanger, the inventor of the first protein, RNA and DNA sequencing methods, has traditionally been seen as a technical scientist, engaged in laboratory bench work and not interested at all in intellectual debates in biology. In his autobiography and commentaries by fellow researchers, he is portrayed as having a trajectory exclusively dependent on technological progress. The scarce historical scholarship on Sanger partially challenges these accounts by highlighting the importance of professional contacts, institutional and disciplinary moves in his career, spanning (...) from 1940 to 1983. This paper will complement such literature by focusing, for the first time, on the transition of Sanger's sequencing strategies from degrading to copying the target molecule, which occurred in the late 1960s as he was shifting from protein and RNA to DNA sequencing, shortly after his move from the Department of Biochemistry to the Laboratory of Molecular Biology, both based in Cambridge (UK). Through a reinterpretation of Sanger's papers and retrospective accounts and a pioneering investigation of his laboratory notebooks, I will claim that sequencing shifted from the working procedures of organic chemistry to those of the emergent molecular biology. I will also argue that sequencing deserves a history in its own right as a practice and not as a technique subordinated to the development of molecular biology or genomics. My proposed history of sequencing leads to a reappraisal of current STS debates on bioinformatics, biotechnology and biomedicine. (shrink)