Anti-Aging and Biomedicine: Critical Studies on the Pursuit of Maintaining, Revitalizing and Enhancing Aging Bodies Content Type Journal Article Category Editorial Notes Pages 187-195 DOI 10.1007/s12376-009-0021-9 Authors Antje Kampf, Johannes Gutenberg-Universität Mainz Mainz Germany Lynn A. Botelho, Indiana University of Pennsylvania Indiana PA USA Journal Medicine Studies Online ISSN 1876-4541 Print ISSN 1876-4533 Journal Volume Volume 1 Journal Issue Volume 1, Number 3.

Research into human ageing is a growing field of research with two central foci: geriatric medicine works to reduce the incidence and severity of age-related diseases and disabilities by devising adequate therapeutic and preventive strategies. A second focus, this time in the emerging field of biogerontology, is to bring about a general retardation of the ageing process and by this increase the average and maximum human lifespan. This contribution looks into the second focus, i.e. the possibility of age retardation which, (...) for the time being, is merely hypothetical. After outlining research strategies studying age retardation in animal experiments, it will ask how extending human life by technological interventions might play out on the individual, familial and social level. The central concern here will be autonomy-linked issues, seeing that in debates concerning the ethical implications of age-retarding techniques the argument from autonomy is one of the main arguments in favour of the prolongation of human life. In particular, this contribution will assess whether the argument from autonomy does, in fact, unequivocally support the recourse to age-retarding techniques. (shrink)

Brain age prediction is a relatively new tool in neuro-medicine and the neurosciences. In research and clinical practice, it finds multiple use as a marker for biological age, for general health status of the brain and as an indicator for several brain-based disorders. Its utility in all these tasks depends on detecting outliers and thus failing to correctly predict chronological age. The indicative value of brain age prediction is generated by the gap between a brain’s chronological age and the predicted (...) age, the brain age gap (BAG). This article shows how the clinical and research use of brain age prediction tacitly pathologizes the states that it is sensitive to. It will be argued that the tacit character of this transformation conceals the need for its explicit justification. (shrink)

Important scientific, ethical and sociological debates are emerging over the trans-humanist goal to achieve therapeutic treatments to ‘cure’ the debilitation of age-related illness and extend the healthy life span of individuals through interventive biogerontological research. The scientific and moral discourses surrounding this contentious scientific field are mapped out, followed by a normative argument favouring ‘strong’ deliberative democratic control of human life extension research. This proposal incorporates insights from constructive and participatory technology assessment, upstream public engagement and back-casting analysis; to outline (...) a programme of participatory approaches to encourage two-way dialogue between scientific and citizen perspectives, and foster the long-term deliberative democratic governance of this developing field. (shrink)

The purpose of this paper is to propose a critique of the prevailing attitude of human health, what I refer to as the will to health, using a Nietzschean perspective. First, I briefly discuss the purpose and manner of Nietzsche’s methodological approach to philosophy and his problem with modernity. Second, I explicate the two current ideological paradigms of health that, in my view, constitute the prevailing will to health. Third, Nietzsche’s general understanding of human health is presented and following this, (...) a critique of some contemporary health matters from this perspective is undertaken. Strictly speaking, there is no specific thesis to be found in this paper. I do not presume to prove or disprove anything, rather I avail myself of Nietzsche’s unique insight into the human condition as a rubric from which to illuminate something of the nature of human health. (shrink)

Responding to a well-known essay by Bernard Williams, philosophers (and a few theologians) have engaged in what I call “the Makropulos debate,” a debate over whether immortality—“living forever”—would be desirable for beings like us. Lacking a firm conceptual grounding in the religious contexts from which terms such as “immortality” and “eternal life” gain much of their sense, the debate has consisted chiefly in a battle of speculative fantasies. Having presented my four main reasons for this assessment, I examine an alternative (...) and neglected conception, the idea of eternal life as a present possession, derived in large part from Johannine Christianity. Without claiming to argue for the truth of this conception, I present its investigation as exemplifying a conceptually fruitful direction of inquiry into immortality or eternal life, one which takes seriously the religious and ethical surroundings of these concepts. (shrink)

This article contributes to the ongoing debate initiated by Bernard Williams’ claim that, due to the non-contingent finitude of the categorical desires that give meaning to our lives, an immortal life would necessarily become intolerably boring. Jeremy Wisnewski has argued that even if immortality involves periods in which our categorical desires have been exhausted, this need not divest life of meaning since some categorical desires are revivable. I argue that careful reflection upon the thought-experiments adduced by Wisnewski reveals that they (...) do not substantiate his proposal, and hence that a plausible reason for rejecting Williams’ position has not been provided. (shrink)

This article reflects upon the debate, initiated by Bernard Williams in 1973, concerning the desirability of immortality, where the latter expression is taken to mean endless bodily life as a human or humanoid being. Williams contends that it cannot be desirable; others have disputed this contention. I discuss a recent response from Timothy Chappell and attempt to pinpoint the central disagreement between Chappell and Williams. I propose that neither side in the debate has firm grounds for its claims, and then (...) proceed to consider four reasons for suspecting that the whole debate has yet to be placed on a conceptually coherent footing. (shrink)

In a well-known paper, Bernard Williams argues that an immortal life would not be worth living, for it would necessarily become boring. I examine the implications for the boredom thesis of three human traits that have received insufficient attention in the literature on Williams’ paper. First, human memory decays, so humans would be entertained and driven by things that they experienced long before but had forgotten. Second, even if memory does not decay to the extent necessary to ward off boredom, (...) once-satisfied desires often return after a sufficient period of time. Eternity would always contain sufficient time for our desires to rejuvenate. Third, even if too many of our desires were satisfied but not yet rejuvenated, we can expect that human ingenuity would continue to invent new pursuits, pastimes, careers, and ways of life that would prevent us from becoming bored as we moved from one to another. Finally, I consider and respond to several objections, including the claims that as much variety as I propose to be put into an eternal life is inconsistent with having one character throughout one’s life and that the sort of character change and memory decay I postulate is inconsistent with personal identity. (shrink)

In Humanity’s End: Why We Should Reject Radical Enhancement, Nicholas Agar presents a novel argument against the prospect of radical life-extension. Agar’s argument hinges on the claim that extended lifespans will result in people’s lives being dominated by the fear of death. Here we examine this claim and the surrounding issues in Agar’s discussion. We argue, firstly, that Agar’s view rests on empirically dubious assumptions about human rationality and attitudes to risk, and secondly, that even if those assumptions are granted, (...) the fears that Agar adverts to are unlikely to dominate people’s lives if and when radical life-extension is made possible. Further, we claim that the structure of the decision-making process around life-extension is unlikely to be the way that it would have to be in order for Agar’s claims about fear of death to make sense. Finally, we argue that Agar is implicitly committed to a narrow conception of human value. In response, we suggest that the pursuit of life-extension can itself be seen as an expression of certain important aspects of our distinctively human nature. (shrink)

Boredom has dominated discussions about longevity thanks to Bernard Williams’s influential “The Makropulos Case.” I reveal the presence in that paper of a neglected, additional problem for the long-lived person, namely alienation in the face of unwanted change. Williams gestures towards this problem but does not pursue it. I flesh it out on his behalf, connecting it to what I call the ‘curmudgeonly attitude to change.’ This attitude manifests itself in the tendency, amongst those getting on in years, to observe (...) that things are getting worse. Curmudgeonliness is typically met with dismissal because it often concerns changes that don’t radically inhibit the curmudgeon’s well-being or autonomy. I believe that taking the curmudgeonly attitude more seriously will provide insight into the longer-lived self and its relation to the future. Using Williams’s approach to longevity as the framework, I contend that—as with boredom—a sense of alienation born of curmudgeonliness can become terminal for the subject, rendering her unable to envision the future as a site of worthwhile activity. However, I also uncover ways in which this agential stasis is significantly distinct from boredom and constitutes a different worry and a different risk for the long-lived individual. (shrink)

Biological studies have demonstrated that it is possible to slow the ageing process and extend lifespan in a wide variety of organisms, perhaps including humans. Making use of the findings of these studies, this article examines two problems concerning the effect of life extension on population size and welfare. The first—the problem of overpopulation—is that as a result of life extension too many people will co-exist at the same time, resulting in decreases in average welfare. The second—the problem of underpopulation—is (...) that life extension will result in too few people existing across time, resulting in decreases in total welfare. I argue that overpopulation is highly unlikely to result from technologies that slow ageing. Moreover, I claim that the problem of underpopulation relies on claims about life extension that are false in the case of life extension by slowed ageing. The upshot of these arguments is that the population problems discussed provide scant reason to oppose life extension by slowed ageing. (shrink)

Recent work in the psychology of happiness has led some to conclude that we are unreliable assessors of our lives and that skepticism about whether we are happy is a genuine possibility worth taking very seriously. I argue that such claims, if true, have worrisome implications for procreation. In particular, they show that skepticism about whether many if not most people are well positioned to create persons is a genuine possibility worth taking very seriously. This skeptical worry should not be (...) confused with a related but much stronger version of the argument, which says that all human lives are very bad and not worth starting. I criticize the latter stance, but take seriously the former stance and hope it can be answered in future work. (shrink)

Abstract Of the many ways in which identity is constructed and performed online, few are as strongly ‘anchored’ to existing offline relationships as in online social networks like Facebook and Myspace. These networks utilise profiles that extend our practical, psychological and even corporeal identity in ways that give them considerable phenomenal presence in the lives of spatially distant people. This raises interesting questions about the persistence of identity when these online profiles survive the deaths of the users behind them, via (...) the practice of ‘memorialising’ social network profile pages. I situate these practices within a phenomenology of grief that accounts for the ways in which the dead can persist as moral patients, and show how online survival in this case illuminates an important difference between persons and selves within contemporary philosophy of personal identity. Ultimately, the online persistence of the dead helps bring into view a deep ontological contradiction implicit in our dealings with death: the dead both live on as objects of duty and yet completely cease to exist. Content Type Journal Article Category Special Issue Pages 1-17 DOI 10.1007/s13347-011-0050-7 Authors Patrick Stokes, Philosophy Group, School of Humanities, University of Hertfordshire de Havilland Campus, Hatfield, Hertfordshire AL10 9AB, UK Journal Philosophy & Technology Online ISSN 2210-5441 Print ISSN 2210-5433. (shrink)

Peter Singer has argued that there are good utilitarian reasons for rejecting the prospect of superlongevity: developing technology to double (or more) the average human lifespan. I argue against Singer's view on two fronts. First, empirical research on happiness indicates that the later years of life are (on average) the happiest, and there is no reason to suppose that this trend would not continue if superlongevity were realized. Second, it is argued that there are good reasons to suppose that there (...) will be a certain amount of self-selection: the happiest are more likely to adopt superlongevity technology. This means that the adoption of superlongevity technology will have the effect of raising the level of aggregate utility. (shrink)

First, what constitutes a person's death? It is clear enough that people die when their lives end, but less clear what constitutes the ending of a person's life.

To the extent that the performance of embodied and situated cognitive agents is predicated on fore- thought;such agents must remember; and learn from; the past to predict the future. In complex; non-stationaryenvironments; such learning is facilitated by an intrinsic motivation to seek novelty. A significant part of anagent’s identity is thus constituted by its remembered distilled cumulative life experience; which the agent isdriven to constantly expand. The combination of the drive to novelty with practical limits on memorycapacity posits a problem. (...) On the one hand; because novelty seekers are unhappy when bored; merelyreliving past positive experiences soon loses its appeal: happiness can only be attained sporadically; via anopen-ended pursuit of new experience. On the other hand; because the experiencer’s memory is finite;longevity and continued novelty; taken together; imply eventual loss of at least some of the stored content;and with it a disruption of the constructed identity. In this essay; I examine the biobehavioral and cognitive-computational circumstances that give rise to this problem and explore its implications for the humancondition. (shrink)

This paper provides both an overview of and a personal perspective on the field of ‘anti-ageing’. In the late 20th century, progress in the science of ageing re-invigorated activity designed to avoid biological ageing. For some the objective was to abolish the need to die of old age. This anti-ageing movement includes a diverse range of people: hard scientists working in well-funded and established university laboratories, slick corporate-marketing executives and new-age entrepreneurs selling herbal elixirs. The movement has attracted anti-anti-ageing critical (...) comment from three sources: moral critique located in philosophy and religion, scepticism from established scientists in the field of biology and gerontology, and challenge from critical social gerontology. Anti-ageing activists have labelled their critics as ‘conservative’ for opposing the inevitable progress of science. The paper argues that the alternative perspective, which sees the anti-ageing movement as a route by which a biologisation of old age inhibits people from achieving a culturally valued final part to life, is the progressive one. (shrink)

Blackballing the reaper is an old ambition, and considerable progress has been made. For the past 150 years, best-performance life-expectancy (i.e. life-expectancy in the country where it is highest) has increased at a very steady rate of 3 months per year.1 Lifeexpectancy for the ancient Romans was circa 23 years; today the average life-expectancy in the world is 64 years.2 Will this trend continue? What are the consequences if it does? And what ethical and political challenges does the prospect of (...) life-extension create for us today? This article comments on some views on the ethics, science, and politics of lifeextension from a recent edited volume, The Fountain of Youth. (shrink)

Bringing together scholars from philosophy, bioethics, law, sociology, and anthropology, this topical collection explores how innovations in the field of biomedicine and the life sciences are challenging and transforming traditional understandings of human temporality and of the temporal duration, extension and structure of human life. The contributions aim to expand the theoretical debate by highlighting the significance of time and human temporality in different discourses and practical contexts, and developing concrete, empirically informed, and culturally sensitive perspectives. The collection is structured (...) around three main foci: the beginning of life, the middle of life, and later life. This structure facilitates an in-depth examination of specific technological and biographical contexts and at the same time allows an overarching comparison of relevant similarities and differences between life phases and fields of application. (shrink)

What role should sentient animals play in the current debate on enhancement? The question covers several different philosophical fronts that demand urgent global ethical analysis. This touches issues that go from prohibition, permissivity or obligation that should characterize the new biotechnologies oriented to the enhancement of individuals, to the debate surrounding the moral rights of animals. Furthermore, the difficulty arises not only from the controversial moral categories involved, but also from the very extent of the objective proposed. However, this also (...) gives rise to the pertinence of the above-mentioned question posed at the outset: on the one hand, the need for consistency in an eminently biased debate, and on the other the need to justify the proposal in which all sentient individuals are legitimate protagonists without this necessarily leading to implausible scenarios. (shrink)

In the wake of Foucault, the debate on biopolitics has focused on the tensions of bíos and zoé, community and immunity, generation and thanatopolitics. What remains obscure in these accounts is the experiential aspect of life – its unfolding and entanglement with the ageing process. This is true both of approaches that emphasize the ethical implications of the life sciences and those that explore the biopolitical workings of wider social processes. In the contemporary capitalist formation, life’s unfolding is caught up (...) in global flows of information, finance and labour. The organization of the human faculties, the general preconditions for knowledge and communication, becomes central to value creation. And the human body, like fixed capital for Marx, becomes a cost to be amortized as quickly as possible. Investigating these processes with regard to transformations in practices of care provides a means for reassessing current debates regarding the ageing of people and populations. (shrink)

Drawing on Ezekiel Emanuel’s controversial piece ‘Why I hope to die at 75,’ I distinguish two types of concern in ethical debates about extending the human lifespan. The first focusses on the value of living longer from prudential and social perspectives. The second type of concern, which has received less attention, focusses on the value of aiming for longer life. This distinction, which is overlooked in the ethical literature on life extension, is significant because there are features of human psychology (...) and the structure of a life that should give pause when considering how long one should aim to live, but which do not neatly coincide with considerations about how valuable additional life is likely to be. I argue that, while Emanuel’s case for hoping to die at 75 is unconvincing, he nonetheless provides weak pro tanto considerations in favour of taking a moderate life span as a prudential aim around which to base at least some significant life plans. (shrink)

In this article we focus upon the embodiment of vulnerability as an area in which medicine, society and the humanities can be profitably conjoined. We illustrate our argument with two interrelated case studies of narratives of the embodiment of ageing and longevity. First, we draw upon Leoš Janáček’s opera The Makropulos Case (1926) as a locus for debates about human longevity. Second, we discuss 70-year-old Janáček’s decade of unrequited love for a woman 37 years younger than himself, through an examination (...) of their intimate letters. We suggest that both the opera and elements of Janáček’s biography illuminate the passionate emotions that are often hidden behind ‘the mask of ageing’. Finally, we propose that a focus on the embodiment of vulnerability is a productive catalyst for research on narratives of ageing. (shrink)