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  1. Are There Moral Differences Between Maternal Spindle Transfer and Pronuclear Transfer?César Palacios-González - 2017 - Medicine, Health Care and Philosophy 20 (4):503-511.
    This paper examines whether there are moral differences between the mitochondrial replacement techniques that have been recently developed in order to help women afflicted by mitochondrial DNA diseases to have genetically related children absent such conditions: maternal spindle transfer and pronuclear transfer. Firstly, it examines whether there is a moral difference between MST and PNT in terms of the divide between somatic interventions and germline interventions. Secondly, it considers whether PNT and MST are morally distinct under a therapy/creation optic. Finally, (...)
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  • Mitochondrial Replacement Techniques: Genetic Relatedness, Gender Implications, and Justice.César Palacios-González & Tetsuya Ishii - 2017 - Gender and the Genome 1 (4):1-6.
    In 2015 the United Kingdom (UK) became the first nation to legalize egg and zygotic nuclear transfer procedures using mitochondrial replacement techniques (MRTs) to prevent the maternal transmission of serious mitochondrial DNA diseases to offspring. These techniques are a form of human germline genetic modification and can happen intentionally if female embryos are selected during the MRT clinical process, either through sperm selection or preimplantation genetic diagnosis (PGD). In the same year, an MRT was performed by a United States (U.S.)-based (...)
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  • Tri-Parent Baby Technology and Preservation of Lineage: An Analysis From the Perspective of Maqasid Al-Shari’Ah Based Islamic Bioethics.Abdul Halim Ibrahim, Noor Naemah Abdul Rahman, Shaikh Mohd Saifuddeen & Madiha Baharuddin - 2019 - Science and Engineering Ethics 25 (1):129-142.
    Tri-parent baby technology is an assisted reproductive treatment which aims to minimize or eliminate maternal inheritance of mutated mitochondrial DNA. The technology became popular following the move by the United Kingdom in granting license to a group of researchers from the Newcastle Fertility Centre, Newcastle University to conduct research on the symptoms of defective mtDNA. This technology differs from other assisted reproductive technology because it involves the use of gamete components retrieved from three different individuals. Indirectly, it affects the preservation (...)
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  • Mexico and Mitochondrial Replacement Techniques: What a Mess.César Palacios-González - 2018 - British Medical Bulletin 128.
    Abstract Background The first live birth following the use of a new reproductive technique, maternal spindle transfer (MST), which is a mitochondrial replacement technique (MRT), was accomplished by dividing the execution of the MST procedure between two countries, the USA and Mexico. This was done in order to avoid US legal restrictions on this technique. -/- Sources of data Academic articles, news articles, documents obtained through freedom of information requests, laws, regulations and national reports. -/- Areas of agreement MRTs are (...)
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  • Lesbian Motherhood and Mitochondrial Replacement Techniques: Reproductive Freedom and Genetic Kinship.Giulia Cavaliere & César Palacios-González - 2018 - Journal of Medical Ethics 44 (12):835-842.
    In this paper, we argue that lesbian couples who wish to have children who are genetically related to both of them should be allowed access to mitochondrial replacement techniques. First, we provide a brief explanation of mitochondrial diseases and MRTs. We then present the reasons why MRTs are not, by nature, therapeutic. The upshot of the view that MRTs are non-therapeutic techniques is that their therapeutic potential cannot be invoked for restricting their use only to those cases where a mitochondrial (...)
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