This article offers a historical perspective on the bearing of the Christian tradition on humans’ ethical relations with other animals. Instead of focusing on major theologians and canonical texts, this article turns to the initiatives taken by laity and clergy in the mobilization of their antivivisection cause in the last quarter of the 19th century. It reveals that despite the lack of institutional support from major Churches, many reformers sympathetic to Christian ideals relied on Christianity as their moral foundation, utilizing (...) various recourses associated with it in their fight against animal experimentation. These reformers appropriated the concepts of sin and self-sacrifice and the notion of the incarnate Christ, as well as critiques against scientific knowledge and materialism permeating the wider conflict between religion and science at the time. In this wideranging mobilization of resources associated with the Christian religious tradition, they sustained a generation of activism against animal experimentation while, at the same time, recreating a positive Christian subtradition in animal ethics. (shrink)