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  1. A Complementary Account of Scientific Modelling: Modelling Mechanisms in Cancer Immunology.Martin Zach - forthcoming - British Journal for the Philosophy of Science.
    According to a widely held view, scientific modelling consists in entertaining a set of model descriptions that specify a model. Rather than studying the phenomenon of interest directly, scientists investigate the phenomenon indirectly via a model in the hope of learning about some of the phenomenon’s features. I call this view the description-driven modelling (DDM) account. I argue that although an accurate description of much of scientific research, the DDM account is found wanting as regards the mechanistic modelling found in (...)
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  • Mouse avatars of human cancers: the temporality of translation in precision oncology.Sara Green, Mie S. Dam & Mette N. Svendsen - 2021 - History and Philosophy of the Life Sciences 43 (1):1-22.
    Patient-derived xenografts are currently promoted as new translational models in precision oncology. PDXs are immunodeficient mice with human tumors that are used as surrogate models to represent specific types of cancer. By accounting for the genetic heterogeneity of cancer tumors, PDXs are hoped to provide more clinically relevant results in preclinical research. Further, in the function of so-called “mouse avatars”, PDXs are hoped to allow for patient-specific drug testing in real-time. This paper examines the circulation of knowledge and bodily material (...)
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