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Causality: Models, Reasoning and Inference

New York: Cambridge University Press (2000)

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  1. Counterfactuals and Causal Models: Introduction to the Special Issue.Steven A. Sloman - 2013 - Cognitive Science 37 (6):969-976.
    Judea Pearl won the 2010 Rumelhart Prize in computational cognitive science due to his seminal contributions to the development of Bayes nets and causal Bayes nets, frameworks that are central to multiple domains of the computational study of mind. At the heart of the causal Bayes nets formalism is the notion of a counterfactual, a representation of something false or nonexistent. Pearl refers to Bayes nets as oracles for intervention, and interventions can tell us what the effect of action will (...)
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  • A Causal Model Theory of the Meaning of Cause, Enable, and Prevent.Steven Sloman, Aron K. Barbey & Jared M. Hotaling - 2009 - Cognitive Science 33 (1):21-50.
    The verbs cause, enable, and prevent express beliefs about the way the world works. We offer a theory of their meaning in terms of the structure of those beliefs expressed using qualitative properties of causal models, a graphical framework for representing causal structure. We propose that these verbs refer to a causal model relevant to a discourse and that “A causes B” expresses the belief that the causal model includes a link from A to B. “A enables/allows B” entails that (...)
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  • Norm Conflicts and Conditionals.Niels Skovgaard-Olsen, David Kellen, Ulrike Hahn & Karl Christoph Klauer - 2019 - Psychological Review 126 (5):611-633.
    Suppose that two competing norms, N1 and N2, can be identified such that a given person’s response can be interpreted as correct according to N1 but incorrect according to N2. Which of these two norms, if any, should one use to interpret such a response? In this paper we seek to address this fundamental problem by studying individual variation in the interpretation of conditionals by establishing individual profiles of the participants based on their case judgments and reflective attitudes. To investigate (...)
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  • A note on a sensitivity analysis for unmeasured confounding, and the related E-value.Arvid Sjölander - 2020 - Journal of Causal Inference 8 (1):229-248.
    Unmeasured confounding is one of the most important threats to the validity of observational studies. In this paper we scrutinize a recently proposed sensitivity analysis for unmeasured confounding. The analysis requires specification of two parameters, loosely defined as the maximal strength of association that an unmeasured confounder may have with the exposure and with the outcome, respectively. The E-value is defined as the strength of association that the confounder must have with the exposure and the outcome, to fully explain away (...)
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  • Randomization and Rules for Causal Inferences in Biology: When the Biological Emperor (Significance Testing) Has No Clothes.Kristin Shrader-Frechette - 2011 - Biological Theory 6 (2):154-161.
    Why do classic biostatistical studies, alleged to provide causal explanations of effects, often fail? This article argues that in statistics-relevant areas of biology—such as epidemiology, population biology, toxicology, and vector ecology—scientists often misunderstand epistemic constraints on use of the statistical-significance rule (SSR). As a result, biologists often make faulty causal inferences. The paper (1) provides several examples of faulty causal inferences that rely on tests of statistical significance; (2) uncovers the flawed theoretical assumptions, especially those related to randomization, that likely (...)
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  • Counterfactual Graphical Models for Longitudinal Mediation Analysis With Unobserved Confounding.Ilya Shpitser - 2013 - Cognitive Science 37 (6):1011-1035.
    Questions concerning mediated causal effects are of great interest in psychology, cognitive science, medicine, social science, public health, and many other disciplines. For instance, about 60% of recent papers published in leading journals in social psychology contain at least one mediation test (Rucker, Preacher, Tormala, & Petty, 2011). Standard parametric approaches to mediation analysis employ regression models, and either the “difference method” (Judd & Kenny, 1981), more common in epidemiology, or the “product method” (Baron & Kenny, 1986), more common in (...)
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  • Mediated Confirmation.Tomoji Shogenji - 2017 - British Journal for the Philosophy of Science 68 (3):847-874.
    ABSTRACT This article aims to achieve two things: to identify the conditions for transitivity in probabilistic support in various settings, and to uncover the components and structure of the mediated probabilistic relation. It is shown that when the probabilistic relation between the two propositions, x and z, is mediated by multiple layers of partitions of propositions, the impact x has on z consists of the purely indirect impact, the purely bypass impact, and the mixed impact. It is also shown that (...)
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  • Are Jurors Intuitive Statisticians? Bayesian Causal Reasoning in Legal Contexts.Tamara Shengelia & David Lagnado - 2021 - Frontiers in Psychology 11.
    In criminal trials, evidence often involves a degree of uncertainty and decision-making includes moving from the initial presumption of innocence to inference about guilt based on that evidence. The jurors’ ability to combine evidence and make accurate intuitive probabilistic judgments underpins this process. Previous research has shown that errors in probabilistic reasoning can be explained by a misalignment of the evidence presented with the intuitive causal models that people construct. This has been explored in abstract and context-free situations. However, less (...)
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  • Inductive reasoning about causally transmitted properties.Patrick Shafto, Charles Kemp, Elizabeth Baraff Bonawitz, John D. Coley & Joshua B. Tenenbaum - 2008 - Cognition 109 (2):175-192.
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  • Causal diagrams and change variables.Eyal Shahar & Doron J. Shahar - 2012 - Journal of Evaluation in Clinical Practice 18 (1):143-148.
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  • Causal diagrams, gastroesophageal reflux and erosive oesophagitis.Eyal Shahar - 2013 - Journal of Evaluation in Clinical Practice 19 (5):976-983.
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  • The Problem of Coherence and Truth Redux.Michael Schippers - 2016 - Erkenntnis 81 (4):817-851.
    In “What price coherence?”, Klein and Warfield put forward a simple argument that triggered an extensive debate on the epistemic virtues of coherence. As is well-known, this debate yielded far-reaching impossibility results to the effect that coherence is not conducive to truth, even if construed in a ceteris paribus sense. A large part of the present paper is devoted to a re-evaluation of these results. As is argued, all explications of truth-conduciveness leave out an important aspect: while it might not (...)
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  • Patterns of abduction.Gerhard Schurz - 2008 - Synthese 164 (2):201-234.
    This article describes abductions as special patterns of inference to the best explanation whose structure determines a particularly promising abductive conjecture and thus serves as an abductive search strategy. A classification of different patterns of abduction is provided which intends to be as complete as possible. An important distinction is that between selective abductions, which choose an optimal candidate from given multitude of possible explanations, and creative abductions, which introduce new theoretical models or concepts. While selective abduction has dominated the (...)
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  • On the coherence of higher-order beliefs.Stefan Schubert & Erik J. Olsson - 2012 - Southern Journal of Philosophy 50 (1):112-135.
    Let us by ‘first-order beliefs’ mean beliefs about the world, such as the belief that it will rain tomorrow, and by ‘second-order beliefs’ let us mean beliefs about the reliability of first-order, belief-forming processes. In formal epistemology, coherence has been studied, with much ingenuity and precision, for sets of first-order beliefs. However, to the best of our knowledge, sets including second-order beliefs have not yet received serious attention in that literature. In informal epistemology, by contrast, sets of the latter kind (...)
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  • “If you’d wiggled A, then B would’ve changed”: Causality and counterfactual conditionals.Katrin Schulz - 2011 - Synthese 179 (2):239-251.
    This paper deals with the truth conditions of conditional sentences. It focuses on a particular class of problematic examples for semantic theories for these sentences. I will argue that the examples show the need to refer to dynamic, in particular causal laws in an approach to their truth conditions. More particularly, I will claim that we need a causal notion of consequence. The proposal subsequently made uses a representation of causal dependencies as proposed in Pearl (2000) to formalize a causal (...)
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  • Interlevel Relations and Manipulative Causality.Gero Schwenk - 2006 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 37 (1):99-110.
    The topic of this article is the analysis of the relations between different levels of reality. The core argument is based on considerations of both an epistemology of action and manipulative causality as a criterion of object identity. The argumentation is extended towards the concepts of self-organization and self-regulation. Finally, several views on reduction and the problems of emergence and complexity are discussed.
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  • Is coherence conducive to reliability?Stefan Schubert - 2012 - Synthese 187 (2):607-621.
    A measure of coherence is said to be reliability conducive if and only if a higher degree of coherence (asmeasured) of a set of testimonies implies a higher probability that the witnesses are reliable. Recently, it has been proved that the Shogenji measure of coherence is reliability conducive in restricted scenarios (e.g., Olsson and Schubert, Synthese, 157:297–308, 2007). In this article, I investigate whether the Shogenji measure, or any other coherence measure, is reliability conducive in general. An impossibility theorem is (...)
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  • Grounding in the image of causation.Jonathan Schaffer - 2016 - Philosophical Studies 173 (1):49-100.
    Grounding is often glossed as metaphysical causation, yet no current theory of grounding looks remotely like a plausible treatment of causation. I propose to take the analogy between grounding and causation seriously, by providing an account of grounding in the image of causation, on the template of structural equation models for causation.
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  • Coherence, striking agreement, and reliability: On a putative vindication of the Shogenji measure.Michael Schippers - 2014 - Synthese 191 (15):3661-3684.
    Striving for a probabilistic explication of coherence, scholars proposed a distinction between agreement and striking agreement. In this paper I argue that only the former should be considered a genuine concept of coherence. In a second step the relation between coherence and reliability is assessed. I show that it is possible to concur with common intuitions regarding the impact of coherence on reliability in various types of witness scenarios by means of an agreement measure of coherence. Highlighting the need to (...)
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  • Coherence reasoning and reliability: a defense of the Shogenji measure.Stefan Schubert - 2012 - Synthese 187 (2):305-319.
    A measure of coherence is said to be reliability conducive if and only if a higher degree of coherence (as measured) results in a higher likelihood that the witnesses are reliable. Recently, it has been proved that several coherence measures proposed in the literature are reliability conducive in a restricted scenario (Olsson and Schubert 2007, Synthese 157:297–308). My aim is to investigate which coherence measures turn out to be reliability conducive in the more general scenario where it is any finite (...)
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  • Contrastive causation in the law.Jonathan Schaffer - 2010 - Legal Theory 16 (4):259-297.
    What conception of causation is at work in the law? I argue that the law implicitly relies on a contrastive conception. In a liability case where the defendant's breach of duty must be shown to have caused the plaintiff's damages, it is not enough to consider what would have happened if the cause had not occurredthe law requires us to look to a specific replacement for the effect, which in this case is the hypothetical outcome in which the plaintiff came (...)
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  • Contrastive causation.Jonathan Schaffer - 2005 - Philosophical Review 114 (3):327-358.
    Causation is widely assumed to be a binary relation: c causes e. I will argue that causation is a quaternary, contrastive relation: c rather than C* causes e rather than E*, where C* and E* are nonempty sets of contrast events. Or at least, I will argue that treating causation as contrastive helps resolve some paradoxes.
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  • Coherence and Reliability: The Case of Overlapping Testimonies.Stefan Schubert - 2011 - Erkenntnis 74 (2):263-275.
    A measure of coherence is said to be reliability conducive if and only if a higher degree of coherence (as measured) among testimonies implies a higher probability that the witnesses are reliable. Recently, it has been proved that several coherence measures proposed in the literature are reliability conducive in scenarios of equivalent testimonies (Olsson and Schubert 2007; Schubert, to appear). My aim is to investigate which coherence measures turn out to be reliability conducive in the more general scenario where the (...)
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  • An Informational Perspective on Agency Causation.Christoph Schulz - 2016 - Topoi 35 (1):241-252.
    According to Fred Dretske’s semantic information theory, the process of becoming informed consists of two parts: the transfer of information via a channel, and the subsequent formation of a semantic structure, called ‘digitalisation’. Leaving out any one of the two parts renders the concept of becoming informed incomplete. Similarly, Peter Menzies and Huw Price’s agency-account of causation has a bipartite structure. The account posits that an event A is a cause of a distinct event B in cases where bringing about (...)
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  • Correlational Data, Causal Hypotheses, and Validity.Federica Russo - 2011 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 42 (1):85 - 107.
    A shared problem across the sciences is to make sense of correlational data coming from observations and/or from experiments. Arguably, this means establishing when correlations are causal and when they are not. This is an old problem in philosophy. This paper, narrowing down the scope to quantitative causal analysis in social science, reformulates the problem in terms of the validity of statistical models. Two strategies to make sense of correlational data are presented: first, a 'structural strategy', the goal of which (...)
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  • Are causal analysis and system analysis compatible approaches?Federica Russo - 2010 - International Studies in the Philosophy of Science 24 (1):67 – 90.
    In social science, one objection to causal analysis is that the assumption of the closure of the system makes the analysis too narrow in scope, that is, it considers only 'closed' and 'hermetic' systems thus neglecting many other external influences. On the contrary, system analysis deals with complex structures where every element is interrelated with everything else in the system. The question arises as to whether the two approaches can be compatible and whether causal analysis can be integrated into the (...)
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  • Causal Comparability, Causal Generalizations, and Epistemic Homogeneity.Rosa W. Runhardt - 2017 - Philosophy of the Social Sciences 47 (3):183-208.
    The issue of causal comparability in the social sciences underlies matters of both generalization and extrapolation. After critiquing two existing interpretations of comparability, due to Hitchcock and Hausman, I propose a distinction between ontological and epistemic comparability. While the former refers to whether two cases are actually comparable, the latter respects that in cases of incomplete information, we need to rely on whatever evidence we have of comparability. I argue, using a political science case study, that in those cases of (...)
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  • Causal mechanisms in political science: Andrew Bennett and Jeffrey T. Checkel : Process tracing: From metaphor to analytic tool. Cambridge: Cambridge University Press, 2015, 342pp, $36.99 PB, $99.00 HB.Rosa W. Runhardt - 2015 - Metascience 24 (3):453-456.
    Philosophers of social science have emphasized mechanistic approaches to causal inquiry for some time now, showing why focusing on the mechanisms behind correlations is preferable to focusing on correlations alone (cf. Johnson 2006, Little 1991, Reiss 2007, 2009, Steel 2004, see also King, Keohane, and Verba 1994 for an example of purely correlational research). In Process Tracing: from Metaphor to Analytic Tool, political scientists Andrew Bennett and Jeffrey Checkel present a concrete method for finding evidence of causal mechanisms, process tracing. (...)
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  • A note on efficient minimum cost adjustment sets in causal graphical models.Andrea Rotnitzky & Ezequiel Smucler - 2022 - Journal of Causal Inference 10 (1):174-189.
    We study the selection of adjustment sets for estimating the interventional mean under an individualized treatment rule. We assume a non-parametric causal graphical model with, possibly, hidden variables and at least one adjustment set composed of observable variables. Moreover, we assume that observable variables have positive costs associated with them. We define the cost of an observable adjustment set as the sum of the costs of the variables that comprise it. We show that in this setting there exist adjustment sets (...)
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  • What to say to a skeptical metaphysician: A defense manual for cognitive and behavioral scientists.Don Ross & David Spurrett - 2004 - Behavioral and Brain Sciences 27 (5):603-627.
    A wave of recent work in metaphysics seeks to undermine the anti-reductionist, functionalist consensus of the past few decades in cognitive science and philosophy of mind. That consensus apparently legitimated a focus on what systems do, without necessarily and always requiring attention to the details of how systems are constituted. The new metaphysical challenge contends that many states and processes referred to by functionalist cognitive scientists are epiphenomenal. It further contends that the problem lies in functionalism itself, and that, to (...)
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  • What is social structural explanation? A causal account.Lauren N. Ross - 2023 - Noûs 1 (1):163-179.
    Social scientists appeal to various “structures” in their explanations including public policies, economic systems, and social hierarchies. Significant debate surrounds the explanatory relevance of these factors for various outcomes such as health, behavioral, and economic patterns. This paper provides a causal account of social structural explanation that is motivated by Haslanger (2016). This account suggests that social structure can be explanatory in virtue of operating as a causal constraint, which is a causal factor with unique characteristics. A novel causal framework (...)
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  • Scientific Explanation and Trade-Offs Between Explanatory Virtues.Alirio Rosales & Adam Morton - 2019 - Foundations of Science 26 (4):1075-1087.
    “Explanation” refers to a wide range of activities, with a family resemblance between them. Most satisfactory explanations in a discipline for a domain fail to satisfy some general desiderata, while fulfilling others. This can happen in various ways. Why? An idealizing response would be to say that in real science explanations fall short along some dimensions, so that for any explanatory failure there is a conceivable improvement that addresses its shortcomings. The improvement may be more accurate causally or possess more (...)
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  • Deep trouble for the deep self.David Rose, Jonathan Livengood, Justin Sytsma & Edouard Machery - 2012 - Philosophical Psychology 25 (5):629 - 646.
    Chandra Sripada's (2010) Deep Self Concordance Account aims to explain various asymmetries in people's judgments of intentional action. On this account, people distinguish between an agent's active and deep self; attitude attributions to the agent's deep self are then presumed to play a causal role in people's intentionality ascriptions. Two judgments are supposed to play a role in these attributions?a judgment that specifies the attitude at issue and one that indicates that the attitude is robust (Sripada & Konrath, 2011). In (...)
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  • Why there isn’t inter-level causation in mechanisms.Felipe Romero - 2015 - Synthese 192 (11):3731-3755.
    The experimental interventions that provide evidence of causal relations are notably similar to those that provide evidence of constitutive relevance relations. In the first two sections, I show that this similarity creates a tension: there is an inconsistent triad between Woodward’s popular interventionist theory of causation, Craver’s mutual manipulability account of constitutive relevance in mechanisms, and a variety of arguments for the incoherence of inter-level causation. I argue for an interpretation of the views in which the tension is merely apparent. (...)
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  • Two causal theories of counterfactual conditionals.Lance J. Rips - 2010 - Cognitive Science 34 (2):175-221.
    Bayes nets are formal representations of causal systems that many psychologists have claimed as plausible mental representations. One purported advantage of Bayes nets is that they may provide a theory of counterfactual conditionals, such as If Calvin had been at the party, Miriam would have left early. This article compares two proposed Bayes net theories as models of people's understanding of counterfactuals. Experiments 1-3 show that neither theory makes correct predictions about backtracking counterfactuals (in which the event of the if-clause (...)
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  • Inference and Explanation in Counterfactual Reasoning.Lance J. Rips & Brian J. Edwards - 2013 - Cognitive Science 37 (6):1107-1135.
    This article reports results from two studies of how people answer counterfactual questions about simple machines. Participants learned about devices that have a specific configuration of components, and they answered questions of the form “If component X had not operated [failed], would component Y have operated?” The data from these studies indicate that participants were sensitive to the way in which the antecedent state is described—whether component X “had not operated” or “had failed.” Answers also depended on whether the device (...)
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  • Argumentative Thinking: An Introduction to the Special Issue on Psychology and Argumentation.Lance J. Rips - 2009 - Informal Logic 29 (4):327-336.
    This special issue of Informal Logic brings together a num-ber of traditions from the psychology and philosophy of argument. Psycho-logists’ interest in argument typically arises in understanding how indivi-duals form and change their beliefs. Thus, theories of argument can serve as models of the structure of justi-fications for belief, as methods of diagnosing errors in beliefs, and as prototypes for learning. The articles in this issue illustrate all three of these connections.
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  • The Similarity of Causal Inference in Experimental and Non‐experimental Studies.Richard Scheines - 2005 - Philosophy of Science 72 (5):927-940.
    For nearly as long as the word “correlation” has been part of statistical parlance, students have been warned that correlation does not prove causation, and that only experimental studies, e.g., randomized clinical trials, can establish the existence of a causal relationship. Over the last few decades, somewhat of a consensus has emerged between statisticians, computer scientists, and philosophers on how to represent causal claims and connect them to probabilistic relations. One strand of this work studies the conditions under which evidence (...)
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  • Causality in complex interventions.Dean Rickles - 2009 - Medicine, Health Care and Philosophy 12 (1):77-90.
    In this paper I look at causality in the context of intervention research, and discuss some problems faced in the evaluation of causal hypotheses via interventions. I draw attention to a simple problem for evaluations that employ randomized controlled trials. The common alternative to randomized trials, the observational study, is shown to face problems of a similar nature. I then argue that these problems become especially acute in cases where the intervention is complex (i.e. that involves intervening in a complex (...)
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  • What is epistemically wrong with research affected by sponsorship bias? The evidential account.Alexander Reutlinger - 2020 - European Journal for Philosophy of Science 10 (2):1-26.
    Biased research occurs frequently in the sciences. In this paper, I will focus on one particular kind of biased research: research that is subject to sponsorship bias. I will address the following epistemological question: what precisely is epistemically wrong with biased research of this kind? I will defend the evidential account of epistemic wrongness: that is, research affected by sponsorship bias is epistemically wrong if and only if the researchers in question make false claims about the evidential support of some (...)
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  • A Theory of Non-universal Laws.Alexander Reutlinger - 2011 - International Studies in the Philosophy of Science 25 (2):97 - 117.
    Laws in the special sciences are usually regarded to be non-universal. A theory of laws in the special sciences faces two challenges. (I) According to Lange's dilemma, laws in the special sciences are either false or trivially true. (II) They have to meet the ?requirement of relevance?, which is a way to require the non-accidentality of special science laws. I argue that both challenges can be met if one distinguishes four dimensions of (non-) universality. The upshot is that I argue (...)
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  • Can Interventionists Be Neo-Russellians? Interventionism, the Open Systems Argument, and the Arrow of Entropy.Alexander Reutlinger - 2013 - International Studies in the Philosophy of Science 27 (3):273-293.
    International Studies in the Philosophy of Science, Volume 27, Issue 3, Page 273-293, September 2013.
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  • On the proper formulation of conditionalization.Michael Rescorla - 2021 - Synthese 198 (3):1935-1965.
    Conditionalization is a norm that governs the rational reallocation of credence. I distinguish between factive and non-factive formulations of Conditionalization. Factive formulations assume that the conditioning proposition is true. Non-factive formulations allow that the conditioning proposition may be false. I argue that non-factive formulations provide a better foundation for philosophical and scientific applications of Bayesian decision theory. I furthermore argue that previous formulations of Conditionalization, factive and non-factive alike, have almost universally ignored, downplayed, or mishandled a crucial causal aspect of (...)
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  • A Pragmatist Theory of Evidence.Julian Reiss - 2015 - Philosophy of Science 82 (3):341-362.
    Two approaches to evidential reasoning compete in the biomedical and social sciences: the experimental and the pragmatist. Whereas experimentalism has received considerable philosophical analysis and support since the times of Bacon and Mill, pragmatism about evidence has been neither articulated nor defended. The overall aim is to fill this gap and develop a theory that articulates the latter. The main ideas of the theory will be illustrated and supported by a case study on the smoking/lung cancer controversy in the 1950s.
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  • Categorization as causal reasoning⋆.Bob Rehder - 2003 - Cognitive Science 27 (5):709-748.
    A theory of categorization is presented in which knowledge of causal relationships between category features is represented in terms of asymmetric and probabilistic causal mechanisms. According to causal‐model theory, objects are classified as category members to the extent they are likely to have been generated or produced by those mechanisms. The empirical results confirmed that participants rated exemplars good category members to the extent their features manifested the expectations that causal knowledge induces, such as correlations between feature pairs that are (...)
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  • Causal‐Based Property Generalization.Bob Rehder - 2009 - Cognitive Science 33 (3):301-344.
    A central question in cognitive research concerns how new properties are generalized to categories. This article introduces a model of how generalizations involve a process of causal inference in which people estimate the likely presence of the new property in individual category exemplars and then the prevalence of the property among all category members. Evidence in favor of this causal‐based generalization (CBG) view included effects of an existing feature’s base rate (Experiment 1), the direction of the causal relations (Experiments 2 (...)
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  • Causation, exclusion, and the special sciences.Panu Raatikainen - 2010 - Erkenntnis 73 (3):349-363.
    The issue of downward causation (and mental causation in particular), and the exclusion problem is discussed by taking into account some recent advances in the philosophy of science. The problem is viewed from the perspective of the new interventionist theory of causation developed by Woodward. It is argued that from this viewpoint, a higher-level (e.g., mental) state can sometimes truly be causally relevant, and moreover, that the underlying physical state which realizes it may fail to be such.
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  • The mechanistic approach of The Theory of Island Biogeography and its current relevance.Viorel Pâslaru - 2014 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 45 (1):22-33.
    Philosophers of science have examined The Theory of Island Biogeography by Robert MacArthur and E. O. Wilson (1967) mainly due to its important contribution to modeling in ecology, but they have not examined it as a representative case of ecological explanation. In this paper, I scrutinize the type of explanation used in this paradigmatic work of ecology. I describe the philosophy of science of MacArthur and Wilson and show that it is mechanistic. Based on this account and in light of (...)
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  • Disentangling Mechanisms from Causes: And the Effects on Science.John Protzko - 2018 - Foundations of Science 23 (1):37-50.
    Despite the miraculous progress of science—it’s practitioners continue to run into mistakes, either discrediting research unduly or making leaps of causal inference where none are warranted. In this we isolate two of the reasons for such behavior involving the misplaced understanding of the role of mechanisms and mechanistic knowledge in the establishment of cause-effect relationships. We differentiate causal knowledge into causes, effects, mechanisms, cause-effect relationships, and causal stories. Failing to understand the role of mechanisms in this picture, including their absence (...)
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  • E-Synthesis: A Bayesian Framework for Causal Assessment in Pharmacosurveillance.Francesco De Pretis, Jürgen Landes & Barbara Osimani - 2019 - Frontiers in Pharmacology 10.
    Background: Evidence suggesting adverse drug reactions often emerges unsystematically and unpredictably in form of anecdotal reports, case series and survey data. Safety trials and observational studies also provide crucial information regarding the (un-)safety of drugs. Hence, integrating multiple types of pharmacovigilance evidence is key to minimising the risks of harm. Methods: In previous work, we began the development of a Bayesian framework for aggregating multiple types of evidence to assess the probability of a putative causal link between drugs and side (...)
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