This article addresses a number of phenomena in the field of digital communication - disinformation, infodemics and conspiracy mania - that promote indifference regarding the distinction between truth and lies, fact and fiction, opinion and knowledge. They have thus decisively altered users' patterns of rationality and common sense and contributed to the rise of anti-democratic and anti-scientific positions. To address this complex problem, a systemic approach is provided that considers these phenomena to be factors that disturb the ethical-epistemic equilibrium between (...) uncertainty, trust and responsibility. After identifying a set of dynamics generated by these disruptive factors, three aspects are explored in depth: the polarisation and lack of a deliberative culture, the necessary correction of the social image of scientific practice, and the impact of the post-truth discourse. The article concludes with reflections on redefining the three key concepts of uncertainty, trust and responsibility in light of the demands of the digital sphere. (shrink)