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Buffer zone

Nature 417 (598):599 (2002)

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  1. Hsp90-induced evolution: Adaptationist, neutralist, and developmentalist scenarios.Roberta L. Millstein - 2007 - Biological Theory: Integrating Development, Evolution and Cognition 2 (4):376-386.
    Recent work on the heat-shock protein Hsp90 by Rutherford and Lindquist (1998) has been included among the pieces of evidence taken to show the essential role of developmental processes in evolution; Hsp90 acts as a buffer against phenotypic variation, allowing genotypic variation to build. When the buffering capacity of Hsp90 is altered (e.g., in nature, by mutation or environmental stress), the genetic variation is "revealed," manifesting itself as phenotypic variation. This phenomenon raises questions about the genetic variation before and after (...)
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