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  1. Researcher Views on Changes in Personality, Mood, and Behavior in Next-Generation Deep Brain Stimulation.Peter Zuk, Clarissa E. Sanchez, Kristin Kostick-Quenet, Katrina A. Muñoz, Lavina Kalwani, Richa Lavingia, Laura Torgerson, Demetrio Sierra-Mercado, Jill O. Robinson, Stacey Pereira, Simon Outram, Barbara A. Koenig, Amy L. McGuire & Gabriel Lázaro-Muñoz - 2023 - American Journal of Bioethics Neuroscience 14 (3):287-299.
    The literature on deep brain stimulation (DBS) and adaptive DBS (aDBS) raises concerns that these technologies may affect personality, mood, and behavior. We conducted semi-structured interviews with researchers (n = 23) involved in developing next-generation DBS systems, exploring their perspectives on ethics and policy topics including whether DBS/aDBS can cause such changes. The majority of researchers reported being aware of personality, mood, or behavioral (PMB) changes in recipients of DBS/aDBS. Researchers offered varying estimates of the frequency of PMB changes. A (...)
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  • Personality and Authenticity in Light of the Memory-Modifying Potential of Optogenetics: A Reply to Objections about Potential Therapeutic Applicability of Optogenetics.Agnieszka K. Adamczyk & Przemysław Zawadzki - 2021 - American Journal of Bioethics Neuroscience 15 (2):W4-W7.
    In our article (Zawadzki and Adamczyk 2021), we analyzed threats that novel memory modifying interventions may pose in the future. More specifically, we discussed how optogenetics’ potential for reversible erasure/deactivation of memory “may impact authenticity by producing changes at different levels of personality.” Our article has received many thoughtful open peer commentaries for which we would like to express our great appreciation. We have identified two main threads of objections. They are related to the potential applicability of optogenetics as a (...)
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  • Dimensions of the Threat to the Self Posed by Deep Brain Stimulation: Personal Identity, Authenticity, and Autonomy.Przemysław Zawadzki - 2020 - Diametros 18 (69):71-98.
    Deep Brain Stimulation (DBS) is an invasive therapeutic method involving the implantation of electrodes and the electrical stimulation of specific areas of the brain to modulate their activity. DBS brings therapeutic benefits, but can also have adverse side effects. Recently, neuroethicists have recognized that DBS poses a threat to the very fabric of human existence, namely, to the selves of patients. This article provides a review of the neuroethical literature examining this issue, and identifies the crucial dimensions related to the (...)
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  • Personality and Authenticity in Light of the Memory-Modifying Potential of Optogenetics.Przemysław Zawadzki & Agnieszka K. Adamczyk - 2021 - American Journal of Bioethics Neuroscience 12 (1):3-21.
    There has been a growing interest in research concerning memory modification technologies (MMTs) in recent years. Neuroscientists and psychologists are beginning to explore the prospect of controllable and intentional modification of human memory. One of the technologies with the greatest potential to this end is optogenetics—an invasive neuromodulation technique involving the use of light to control the activity of individual brain cells. It has recently shown the potential to modify specific long-term memories in animal models in ways not yet possible (...)
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  • Pattern theory of self and situating moral aspects: the need to include authenticity, autonomy and responsibility in understanding the effects of deep brain stimulation.Przemysław Zawadzki - 2022 - Phenomenology and the Cognitive Sciences 21 (3):559-582.
    The aims of this paper are to: (1) identify the best framework for comprehending multidimensional impact of deep brain stimulation on the self; (2) identify weaknesses of this framework; (3) propose refinements to it; (4) in pursuing (3), show why and how this framework should be extended with additional moral aspects and demonstrate their interrelations; (5) define how moral aspects relate to the framework; (6) show the potential consequences of including moral aspects on evaluating DBS’s impact on patients’ selves. Regarding (...)
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