This paper employs Michel Foucault’s History of Sexuaity: Confessions of the Flesh to shed light on the perplexing phenomenon of vaccine (mandate) resistance. It argues that vaccine (mandate) resistance, while seemingly irresponsible and selfish, is entangled with the same modes of ‘truth-telling’ that have been part of the basic structure of modern Western governance for centuries. The paper begins by introducing the problem of vaccinate (mandate) resistance as a pedagogical problem for educators who want to teach social responsibility as informed (...) by sound scientific knowledge and research. It then outlines the triad of knowledge/science, power/governance, and subjectivity/being at the heart of Foucault’s research as a necessary frame for understanding the sociopolitical and historical entanglements of science in modern Western governance. Lastly, the paper traces Foucault’s study of early Christian writers such as St. Augustine in terms of how they help establish basic practices of truth-telling that still impact how subjects relate to power today. The ultimate goal of the paper is to show how exploration of the social, historical, and political realities of science related issues are vital for understanding issues of collective existence today. (shrink)