Evidence-based medicine (EBM) makes use of explicit procedures for grading evidence for causal claims. Normally, these procedures categorise evidence of correlation produced by statistical trials as better evidence for a causal claim than evidence of mechanisms produced by other methods. We argue, in contrast, that evidence of mechanisms needs to be viewed as complementary to, rather than inferior to, evidence of correlation. In this paper we first set out the case for treating evidence of mechanisms alongside evidence of correlation in (...) explicit protocols for evaluating evidence. Next we provide case studies which exemplify the ways in which evidence of mechanisms complements evidence of correlation in practice. Finally, we put forward some general considerations as to how the two sorts of evidence can be more closely integrated by EBM. (shrink)

Abstract: According to Laurence BonJour, the problem of induction can be solved by recognizing the a priori necessity that inductive conclusions constitute the best explanations of inductive premises. I defend an interpretation of the key probability claims BonJour makes about inductive premises and show that they are not susceptible to many of the objections that have been lodged against them. I then argue that these purportedly necessary probability claims nevertheless remain deeply problematic and that, as a result, BonJour's proposal fails (...) to provide a satisfactory resolution of the problem of induction. (shrink)

In this paper, I argue that theories of perception that appeal to Helmholtz’s idea of unconscious inference (“Helmholtzian” theories) should be taken literally, i.e. that the inferences appealed to in such theories are inferences in the full sense of the term, as employed elsewhere in philosophy and in ordinary discourse. -/- In the course of the argument, I consider constraints on inference based on the idea that inference is a deliberate acton, and on the idea that inferences depend on the (...) syntactic structure of representations. I argue that inference is a personal-level but sometimes unconscious process that cannot in general be distinguished from association on the basis of the structures of the representations over which it’s defined. I also critique arguments against representationalist interpretations of Helmholtzian theories, and argue against the view that perceptual inference is encapsulated in a module. (shrink)

The vision of natural kinds that is most common in the modern philosophy of biology, particularly with respect to the question whether species and other taxa are natural kinds, is based on a revision of the notion by Mill in A System of Logic. However, there was another conception that Whewell had previously captured well, which taxonomists have always employed, of kinds as being types that need not have necessary and sufficient characters and properties, or essences. These competing views employ (...) different approaches to scientific methodologies: Mill’s class-kinds are not formed by induction but by deduction, while Whewell’s type-kinds are inductive. More recently, phylogenetic kinds (clades, or monophyletic-kinds) are inductively projectible, and escape Mill’s strictures. Mill’s version represents a shift in the notions of kinds from the biological to the physical sciences. (shrink)

Scientists often think of the world as a dynamical system, a stochastic process, or a generalization of such a system. Prominent examples of systems are the system of planets orbiting the sun or any other classical mechanical system, a hydrogen atom or any other quantum–mechanical system, and the earth’s atmosphere or any other statistical mechanical system. We introduce a general and unified framework for describing such systems and show how it can be used to examine some familiar philosophical questions, including (...) the following: how can we define nomological possibility, necessity, determinism, and indeterminism; what are symmetries and laws; what regularities must a system display to make scientific inference possible; how might principles of parsimony such as Occam’s Razor help when we make such inferences; what is the role of space and time in a system; and might they be emergent features? Our framework is intended to serve as a toolbox for the formal analysis of systems that is applicable in several areas of philosophy. (shrink)

When does it make sense to act randomly? A persuasive argument from Bayesian decision theory legitimizes randomization essentially only in tie-breaking situations. Rational behaviour in humans, non-human animals, and artificial agents, however, often seems indeterminate, even random. Moreover, rationales for randomized acts have been offered in a number of disciplines, including game theory, experimental design, and machine learning. A common way of accommodating some of these observations is by appeal to a decision-maker’s bounded computational resources. Making this suggestion both precise (...) and compelling is surprisingly difficult. Toward this end, I propose two fundamental rationales for randomization, drawing upon diverse ideas and results from the wider theory of computation. The first unifies common intuitions in favour of randomization from the aforementioned disciplines. The second introduces a deep connection between randomization and memory: access to a randomizing device is provably helpful for an agent burdened with a finite memory. Aside from fit with ordinary intuitions about rational action, the two rationales also make sense of empirical observations in the biological world. Indeed, random behaviour emerges more or less where it should, according to the proposal. (shrink)

I present an account of deterministic chance which builds upon the physico-mathematical approach to theorizing about deterministic chance known as 'the method of arbitrary functions'. This approach promisingly yields deterministic probabilities which align with what we take the chances to be---it tells us that there is approximately a 1/2 probability of a spun roulette wheel stopping on black, and approximately a 1/2 probability of a flipped coin landing heads up---but it requires some probabilistic materials to work with. I contend that (...) the right probabilistic materials are found in reasonable initial credence distributions. I note that, with some normative assumptions, the resulting account entails that deterministic chances obey a variant of Lewis's 'principal principle'. I additionally argue that deterministic chances, so understood, are capable of explaining long-run frequencies. (shrink)

How should probabilities be interpreted in causal models in the social and health sciences? In this paper we take a step towards answering this question by investigating the case of cancer in epidemiology and arguing that the objective Bayesian interpretation is most appropriate in this domain.

I defend a three-fold form of pluralism about chance, involving a tripartite distinction between propensities, probabilities, and frequencies. The argument has a negative and a positive part. Negatively, I argue against the identity thesis that informs current propensity theories, which already suggests the need for a tripartite distinction. Positively, I argue that that a tripartite distinction is implicit in much statistical practice. Finally, I apply a well-known framework in the modelling literature in order to characterize these three separate concepts functionally (...) in terms of their roles in modelling practice. (shrink)