The bioethical principle of autonomy is problematic regarding the future of the embryo who lacks the ability to self-advocate but will develop this defining human capacity in time. Recent experiments explore the use of clustered regularly interspaced short palindromic repeats /Cas9 for germline engineering in the embryo, which alters future generations. The embryo’s inability to express an autonomous decision is an obvious bioethical challenge of germline engineering. The philosopher Joel Feinberg acknowledged that autonomy is developing in children. He advocated that (...) to reserve this future autonomy, parents should be guided to make ethical decisions that provide children with open futures. Here, Feinberg’s 1980 open future theory is extended to the human embryo in the context of CRISPR germline engineering. Although the embryo does not possess the autonomous decision-making capacity at the time of germline engineering, the parental decision to permanently change the unique genetic fabric of the embryo and subsequent generations disregards future autonomy. Therefore, germline engineering in many instances is objectionable considering Feinberg’s open future theory. (shrink)

Las células madre embrionarias humanas son células pluripotentes con potenciales aplicaciones en medicina regenerativa e interés considerable en investigación y biotecnología. Sin embargo, dada la estrecha relación con principios morales y bioéticos, ha existido una considerable discusión sobre la posibilidad de patentar o no este tipo de células madre. En el presente artículo, se revisa la legislación europea en materia de propiedad industrial, y la tradición del sistema jurídico continental en el reconocimiento de la dignidad humana como principio fundamental y (...) su relación con la protección de invenciones biotecnológicas, centrados en la reciente sentencia del caso Brüstle v. Greenpeace e.V. (shrink)