Deleuze’s “transcendental empiricism” and the “empirical side” of Whitehead’s metaphysics are paradoxical unless placed in the context of their unorthodox readings of empiricism. I explore this context focusing on their engagements with Hume. Both subvert presumptions of a categorical gap between external nature and internal human experience and open possibilities for a speculative empiricism that is non-reductive while still affirming experience as source for philosophical thinking. Deleuze and Whitehead follow Hume in beginning with events of sensation as primary but do (...) not presume the logic of (human) subjects and objects (of nature) as necessary structuring polarities for their interpretation. This challenges a basic distinction (between inner and outer or between self and world) that seems inherent in the ordinary concept of experience, thus earning the moniker speculative. The speculative empiricist studies how these abstractions arise from events of experience prior to their consolidation in representation. This includes a critical component: to what extent do unexamined assumptions about conceptual abstraction hinder, block, or prefigure experiential attention? This critical component has existential implications for how we attend to the affective, intuitive, and preconceptual. (shrink)