This essay is concerned with the epistemic roles of error in scientific practice. Usually, error is regarded as something negative, as an impediment or obstacle for the advancement of science. However, we also frequently say that we are learning from error. This common expression suggests that the role of error is not—at least not always—negative but that errors can make a fruitful contribution to the scientific enterprise. My paper explores the latter possibility. Can errors play an epistemically productive role in (...) scientific research? The paper begins with a review of several twentieth-century approaches to error and the various agendas behind them. It is shown that only very few scholars have considered whether errors can be productive. The main part of the paper examines a concrete debate in early nineteenth-century microscopy and analyses how the microscopists coped with the problem of error. Drawing on this material, the article offers some terminological clarifications of the common notion ‘learning from error’. The conclusion argues that error can indeed play epistemically productive roles in scientific practice.Keywords: Error; Nineteenth-century microscopic anatomy. (shrink)

Observation and experiment as categories for analysing scientific practice have a long pedigree in writings on science. There has, however, been little attempt to delineate observation and experiment with respect to analysing scientific practice; in particular, scientific experimentation, in a systematic manner. Someone who has presented a systematic account of observation and experiment as categories for analysing scientific experimentation is Ian Hacking. In this paper, I present a detailed analysis of Hacking’s observation versus experiment account. Using a range of cases (...) from various fields of scientific enquiry, I argue that the observation versus experiment account is not an adequate framework for delineating scientific experimentation in a systematic manner. (shrink)

Epistemology of science is currently polarized. Descriptive accounts of the social aspects of science coexist uneasily with normative accounts of scientific knowledge. This tension leads students of science to privilege one of these important aspects over the other. I use an episode of recent immunology research to develop an integrative account of scientific inquiry that resolves the tension between sociality and epistemic success. The search for the hematopoietic stem cell by members of Irving Weissman’s laboratory at Stanford University Medical Center (...) exhibits both the goal-oriented character of contemporary immunology and the importance of social interactions in successful achievement of those goals. This episode includes three kinds of epistemic success: characterization of HSC, formation of new interdisciplinary interfaces, and reconciliation of apparently incompatible models. All three depend on coordinating the work of diverse participants via social interactions. Together, they reveal the crucial role of social interactions within and between research groups in producing epistemic success. These features of the search for the HSC generalize to immunology as a whole, and plausibly to other disciplines. This account thus resolves the polarizing tension in epistemology of science, and complements individualistic accounts of scientific knowledge and rationality. (shrink)

: Where there are cases of underdetermination in scientific controversies, such as the case of the molecular clock, scientists may direct the course and terms of dispute by playing off the multidimensional framework of theory evaluation. This is because assessment strategies themselves are underdetermined. Within the framework of assessment, there are a variety of trade-offs between different strategies as well as shifting emphases as specific strategies are given more or less weight in assessment situations. When a strategy is underdetermined, scientists (...) can change the dynamics of a controversy by making assessments using different combinations of evaluation strategies and/or weighting whatever strategies are in play in different ways. Following an underdetermination strategy does not end or resolve a scientific dispute. Consequently, manipulating underdetermination is a feature of controversy dynamics and not controversy closure. (shrink)

The past quarter century has seen an enormous growth of interest among scholars of science and technology in both particular experimental episodes and the process of experimentation. Among the most influential accounts have been those developed by Allan Franklin (1986, 1990), Deborah Mayo (1996) and Peter Galison (1987), each of which was developed primarily with reference to examples drawn from the history of physics. One useful way to access the generality of an account of experiment is to see how it (...) fares with reference to examples drawn from disciplines far removed from the context within which it was developed. In previous essays I examined and compared the adequacy of Franklin and Mayo’s views on experiment with reference to an episode drawn from the history of evolutionary biology, H.B.D. Kettlewell's classic studies of the phenomenon of industrial melanism (Rudge 1998, 2001). The present essay reanalyzes Kettlewell’s work once more, this time as a test of Peter Galison’s provocative account of experimentation in the sciences. Kettlewell’s investigations can indeed be interpreted within Galison’s perspective, but this appears to reflect the vagueness of many key distinctions Galison makes more than any special insights his views provide on the nature of experimentation in evolutionary biology. (shrink)