This article explores the limits of secular philosophy and philosophical reason. It argues that once one abandons God, philosophical reason is unable to establish any particular bioethics or understanding of morality as canonical; that is, as definitively true and binding. Philosophy simply cannot secure the truth of any particular account of the right, the good, the just, or the virtuous. Once one abandons God, all is approached as if it were without ultimate meaning. Throughout, the article explores H. Tristram Engelhardt (...) Jr’s arguments in After God: Morality and Bioethics in a Secular Age, which confronts this major intellectual and cultural crisis. As Engelhardt remind us, traditional Christianity is not a life-style choice, much less another meta-narrative that one chooses and writes for oneself. It is an encounter with God, Who changes everything. Christian bioethics must be appreciated in terms of an encounter with and an authentic experience of God, Whose commands will routinely conflict with the moral dictates of secular morality. (shrink)