Eric Scerri has argued that chemists using ab initio calculations pursue a partial reduction of chemistry to physics, while accepting that full reduction (through axiomatization) is impractical. He characterizes this view as Popperian and naturalistic. However, Popper's position on reduction is not naturalistic, as he rejected axiomatization for different reasons.

In this rejoinder to Eric Scerri's response to my first comment on his paper on the reduction of chemistry to physics, the main point concerns laws in chemistry. But other themes touched upon include the assumptions involved in ab initio calculations, the question of what is reduced to what on Scerri's view, and the significance he attaches to the term "naturalism".