In the 1950s, embryology in socialist China underwent a series of changes that adjusted the disciplinary apparatus to suit socialism and the national goal of self-reliance. As the Communist state called on scientists to learn from the Soviets, embryologists’ comprehensive view on heredity, which did not contradict Trofim Lysenko (1898–1976)’s doctrines, provided a space for them to advance their discipline. Leading scientists, often trained abroad in the tradition of experimental embryology, rode on the tides of Maoist ideology and repositioned their (...) research. Some of their creative realignment of previous research questions, materials, and traditions to Marxist philosophy and agricultural objectives generated productive programs. In particular, Tong Dizhou (1902–1979) translated Engels’s dialectics of nature into a research question about cytoplasmic inheritance. His continuing investigation on it led to the first goldfish “clone” through a nuclear transplantation experiment; Zhu Xi and his associates transferred a goldfish model in embryology into studies on improving carp aquaculture, leading to a rare success in the Great Leap Forward of 1958. These directions for embryology continued well into the 1960s. At a time when global embryology was diversifying and began to be molecularized, eventually forming “developmental biology,” socialist embryology took shape in China with a different set of epistemic and practical commitments. The history of its development challenges and enriches our understanding of the concrete process of change in one discipline under Mao, showing ways in which scientists creatively adapted state-sanctioned ideologies and visions to do productive work outside the framework of molecular biology during the Cold War. (shrink)