This article presents the making of a safe innovation: the application of ice structuring protein (ISP) in edible ices. It argues that safety is not the absence of risk but is an active accomplishment; innovations are not made safe afterward but safe innovations are made. Furthermore, there are multiple safeties to be accomplished in the innovation process. These are financial, public, scientific, and regulatory safety. The negotiations between these safeties determine the material and labeling characteristics of what ISP has become. (...) Not just laboratory researchers but experts from various parts of Unilever, the corporation that produces ISP, participate in accomplishing safety. The safeties they make, interact, overlap, are occasionally in conflict with one another, and continuously connect to outside actors. (shrink)