Using the evolution of the stickleback family of subarctic fish as a touchstone, we explore the effect of new discoveries about regulatory genetics, developmental plasticity, and epigenetic inheritance on the conceptual foundations of the Modern Evolutionary Synthesis. Identifying the creativity of natural selection as the hallmark of the Modern Synthesis, we show that since its inception its adherents have pursued a variety of research projects that at first seemed to conflict with its principles, but were accommodated. We situate challenges coming (...) from developmental biology in a dialectic between innovation and tradition, suggesting on the basis of past episodes that even if developmental plasticity and epigenetic inheritance are aligned with its principles the Modern Synthesis will be significantly affected. (shrink)

Evolutionary adaptation has been suggested as the hallmark of life that best accounts for life’s creativity. However, current evolutionary approaches still fail to give an adequate account of it, even if they are able to explain both the origin of novelties and the proliferation of certain traits in a population. Although modern-synthesis Darwinism is today usually appraised as too narrow a position to cope with all the complexities of developmental and structural biology—not to say biosemiotic phenomena—, Darwinism need not be (...) if we separate metaphor from reality in natural selection in order to show the axiological complexity of this concept. This can shed light on the relationship between biosemiotics and biological evolution. (shrink)

Is organicism inherently Christian-friendly, and for that matter, is mechanism inherently religion nonfriendly? They have tended to be, but the story is much more complicated. The long history of the intertwined metaphors of nature taken as an organism, versus that of nature as a machine, reveals that both metaphors have flourished in the endeavors of philosophers, scientists, and persons of faith alike. Different kinds of Christians have been receptive to both organicist and mechanistic models, just as various kinds of nonreligious (...) scientists have been receptive to both holistic and machine metaphors. Although, it is true, organicism has been generally more attractive to persons of faith than mechanism, an overview of the rich and varied history of allegiances to these metaphors—religious and nonreligious alike—shows that debate is much more interesting and complex. A brief inspection of conversation surrounding recent scientific discoveries shows that this debate between metaphors is still very much alive today. (shrink)

We are grateful to the commentators for taking the time to respond to our article. Too many interesting and important points have been raised for us to tackle them all in this response, and so in the below we have sought to draw out the major themes. These include problems with both the term ‘ultimate causation’ and the proximate-ultimate causation dichotomy more generally, clarification of the meaning of reciprocal causation, discussion of issues related to the nature of development and phenotypic (...) plasticity and their roles in evolution, and consideration of the need for an extended evolutionary synthesis. (shrink)

Biologists employ a suggestive metaphor to describe the complexities of molecular interactions within cells and embryos: cytological components are said to be part of “ecosystems” that integrate them in a complex network of relations with many other entities. The aim of this essay is to scrutinize the molecular ecosystem, a metaphor that, despite its longstanding history, has seldom be articulated in detail. I begin by analyzing some relevant analogies between the cellular environment and the biosphere. Next, I discuss the applicability (...) of the molecular ecosystem concept in actual scientific practice. (shrink)

In spite of its success, Neo-Darwinism is faced with major conceptual barriers to further progress, deriving directly from its metaphysical foundations. Most importantly, neo-Darwinism fails to recognize a fundamental cause of evolutionary change, “niche construction”. This failure restricts the generality of evolutionary theory, and introduces inaccuracies. It also hinders the integration of evolutionary biology with neighbouring disciplines, including ecosystem ecology, developmental biology, and the human sciences. Ecology is forced to become a divided discipline, developmental biology is stubbornly difficult to reconcile (...) with evolutionary theory, and the majority of biologists and social scientists are still unhappy with evolutionary accounts of human behaviour. The incorporation of niche construction as both a cause and a product of evolution removes these disciplinary boundaries while greatly generalizing the explanatory power of evolutionary theory. (shrink)

This essay analyzes the medical study of “monstrous birth” as a site of race-making in the nineteenth-century United States. It argues that the medical theorization of monstrosity was structured by multiple logics of race, which both shaped and emerged from medical authorities’ efforts to classify and interpret anomalous newborn bodies. Materialized at the intersection of these logics, the biological monster theorized a racial order that was hierarchical, temporalized, and vulnerable to the dangers of women’s reproduction. In this context, monstrosity became (...) a way to advance claims about the nature of racial hierarchy, articulate the threat and mechanism of racial degeneration, and negotiate the contradictions of shifting racial imaginaries across the nineteenth century. Exploring the medical engagement with monstrosity thus sheds light on entanglements of medical science and race-making in U.S. history, showing how practitioners produced and elaborated unstable concepts of scientific race, and revealing how race was linked to reproduction in the emergence of modern biomedical discourse. (shrink)