This paper is about the interaction and the intertwinement between history of science as a historical process and history of science as the historiography of this process, taking molecular biology as an example. In the first part, two historical shifts are briefly characterized that appear to have punctuated the emergence of molecular biology between the 1930s and the 1980s, one connected to a new generation of analytical apparatus, the other to properly molecular tools. The second part concentrates on the historiography (...) of this development. Basically, it distinguishes three phases. The first phase was largely dominated by accounts of the actors themselves. The second coincided with the general ‘practical turn’ in history of science at large, and today’s historical appropriations of the molecularization of the life sciences appear to be marked by the changing disciplinary status of the science under review. In a closing remark, an argument is made for differentiating between long-range, middle-range and short-range perspectives in dealing with the history of the sciences. (shrink)

Microstudies and big picture accounts are often counterposed. This paper investigates the supposed dichotomy between the two historiographical approaches. In particular it investigates how the discussions are reflected in the historiography of molecular biology and the special questions posed by the disciplinary context. Taking inspiration from the microhistory tradition as exemplified by the works of Carlo Ginzburg, Jacques Revel, and David Sabean among others, the paper highlights the heuristic value of microstudies to reconstruct the multiple contexts that link apparently small (...) events with broader structures. In a parallel fashion, the paper argues for using microstudies to open up the history of molecular biology to other fields of study and thus moving beyond the confines of the disciplinary framework. Such an approach does not dismiss the search for big pictures. Yet rather than opposing big pictures to microstudies, it sees microstudies as a valid way to gain new and broad vistas. (shrink)