In this study, falsification-aware semantics and sequent calculi for first-order classical logic are introduced and investigated. These semantics and sequent calculi are constructed based on a falsification-aware setting for first-order Nelson constructive three-valued logic. In fact, these semantics and sequent calculi are regarded as those for a classical variant of N3. The completeness and cut-elimination theorems for the proposed semantics and sequent calculi are proved using Schütte’s method. Similar results for the propositional case are also obtained.