There are two important philosophical research programmes on explanation in the twentieth century—the search for an account or model of scientific explanation, and the defence of inference to the best explanation as a rational form of inference. These two research programmes have largely developed independently from one another. This paper argues that bringing the two research programmes in contact promises to yield fruitful discussion. I consider and reject two arguments for keeping the two research programmes separate. I outline several issues (...) related to both research programmes that would benefit from inter(sub)disciplinary dialogue. (shrink)