Interactionists hold that minds are non-physical objects that interact with brains. The neural discernment problem for interactionism is that of explaining how non-physical minds produce behavior and cognition by exercising different causal powers over physiologically similar neurons. This paper sharpens the neural discernment problem and proposes two interactionist models of mind-brain interaction that solve it. One model avoids overdetermination while the other respects the causal closure of the physical domain.