Several recent accounts of modeling have focused on the modal dimension of scientific inquiry. More precisely, it has been suggested that there are specific models and modeling practices that are best understood as being geared towards possibilities, a view recently dubbed modal modeling. But modalities encompass much more than mere possibility claims. Besides possibilities, modal modeling can also be used to investigate contingencies, necessities or impossibilities. Although these modal concepts are logically connected to the notion of possibility, not all models (...) are equal in their affordances for these richer modal inferences. This paper investigates the modal extent of selected models and argues that analyzing singular model-target pairings by themselves is typically not enough to explain their modal aptness or to identify the kinds of modalities they can be used to reason about. Furthermore, it is argued that some important concepts that are not explicitly modal - like biological robustness - can be understood modally through their relational nature to a background space of possibilities. In conclusion, it is suggested that the strategy of modal modeling is contrastive, situating particular possibilities in larger modal spaces and studying the structural relations within them. (shrink)

This article examines how minimal genome research mobilizes philosophical concepts such as minimality and essentiality. Following a historical approach the article aims to uncover what function this terminology plays and which problems are raised by them. Specifically, four historical moments are examined, linked to the work of Harold J. Morowitz, Mitsuhiro Itaya, Eugene Koonin and Arcady Mushegian, and J. Craig Venter. What this survey shows is a historical shift away from historical questions about life or descriptive questions about specific organisms (...) towards questions that explore biological possibilities: what are possible forms of minimal genomes, regardless of whether they exist in nature? Moreover, it highlights a fundamental ambiguity at work in minimal genome research between a universality claim and a standardization claim: does a minimal genome refer to the minimal gene set for any organism whatsoever? Or does it refer rather to a gene set that will provide stable, robust and predictable behaviour, suited for biotechnological applications? Two diagnoses are proposed for this ambiguity: a philosophical diagnosis of how minimal genome research either misunderstands the ontology of biological entities or philosophically misarticulates scientific practice. Secondly, a historical diagnosis that suggests that this ambiguity is part of a broader shift towards technoscience. (shrink)