In this paper I reconstruct and critically examine the reasoning leading to the famous prediction of the ‘omega minus’ particle by M. Gell-Mann and Y. Ne’eman (in 1962) on the basis of a symmetry classification scheme. While the peculiarity of this prediction has occasionally been noticed in the literature, a detailed treatment of the methodological problems it poses has not been offered yet. By spelling out the characteristics of this type of prediction, I aim to underscore the challenges raised by (...) this episode to standard scientific methodology, especially to the traditional deductive-nomological account of prediction. (shrink)