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  1. Non-static framework for understanding adaptive designs: an ethical justification in paediatric trials.Michael O. S. Afolabi & Lauren E. Kelly - 2021 - Journal of Medical Ethics 48 (11):825-831.
    Many drugs used in paediatric medicine are off-label. There is a rising call for the use of adaptive clinical trial designs in responding to the need for safe and effective drugs given their potential to offer efficiency and cost-effective benefits compared with traditional clinical trials. ADs have a strong appeal in paediatric clinical trials given the small number of available participants, limited understanding of age-related variability and the desire to limit exposure to futile or unsafe interventions. Although the ethical value (...)
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