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  1. B‐cell acute lymphoblastic leukaemia: towards understanding its cellular origin.César Cobaleda & Isidro Sánchez-García - 2009 - Bioessays 31 (6):600-609.
    B‐cell acute lymphoblastic leukaemia (B‐ALL) is a clonal malignant disease originated in a single cell and characterized by the accumulation of blast cells that are phenotypically reminiscent of normal stages of B‐cell differentiation. B‐ALL origin has been a subject of continuing discussion, given the fact that human disease is diagnosed at late stages and cannot be monitored during its natural evolution from its cell of origin, although most B‐ALLs probably start off with chromosomal changes in haematopoietic stem cells. However, the (...)
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