William James’s lead continues to provide a balancing act of inquiry and truth with plurality and conflict. First, this article considers this balancing act in neuroscience, both what we have been learning since James published The Principles of Psychology and in how neuroscience is done. As pragmatists have long argued against dualisms and absolutes, the authors situate contemporary understanding in its historical context. Humans have evolved as brains-in-bodies-in-cultures and navigate such worlds through good-enough strategies, not a disembodied reason. Embodied intelligence (...) is laden with instinct, habit, and emotion as much as it is about consciousness. Truth, for James, is focused on nuanced success outcomes, both modest and broad. James’s sense of fallibility is critical in terms of comfort and discomfort in a social group. More prosocial behavior tends to be honest and less sociopathic, of course unless it is myopic and only in group orientation, which it often is. Understanding ourselves through the neuroscience does not answer most of the questions nor solve all the problems. However, such understanding is an important tool in aiding our coping efforts, especially regarding contemporary life. (shrink)