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  1. The Ableism of Quality of Life Judgments in Disorders of Consciousness: Who Bears Epistemic Responsibility?Joel Michael Reynolds - 2016 - American Journal of Bioethics Neuroscience 7 (1):59-61.
    In this peer commentary on L. Syd M. Johnson’s “Inference and Inductive Risk in Disorders of Consciousness,” I argue for the necessity of disability education as an integral component of decision-making processes concerning patients with DOC and, mutatis mutandis, all patients with disabilities. The sole qualification Johnson places on such decision-making is that stakeholders are educated about and “understand the uncertainties of diagnosis and prognosis.” Drawing upon research in philosophy of disability, social epistemology, and health psychology, I argue that this (...)
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  • (2 other versions)Introduction.John A. Robertson - 2010 - Journal of Law, Medicine and Ethics 38 (2):175-190.
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  • Mapping the Ethical Issues of Brain Organoid Research and Application.Tsutomu Sawai, Yoshiyuki Hayashi, Takuya Niikawa, Joshua Shepherd, Elizabeth Thomas, Tsung-Ling Lee, Alexandre Erler, Momoko Watanabe & Hideya Sakaguchi - 2022 - American Journal of Bioethics Neuroscience 13 (2):81-94.
    In 2008, researchers created human three-dimensional neural tissue – known as the pioneering work of “brain organoids.” In recent years, some researchers have transplanted human brain organoids into animal brains for applicational purposes. With these experiments have come many ethical concerns. It is thus an urgent task to clarify what is ethically permissible and impermissible in brain organoid research. This paper seeks (1) to sort out the ethical issues related to brain organoid research and application and (2) to propose future (...)
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  • A framework for the ethical assessment of chimeric animal research involving human neural tissue.Sebastian Porsdam Mann, Rosa Sun & Göran Hermerén - 2019 - BMC Medical Ethics 20 (1):10.
    Animal models of human diseases are often used in biomedical research in place of human subjects. However, results obtained by animal models may fail to hold true for humans. One way of addressing this problem is to make animal models more similar to humans by placing human tissue into animal models, rendering them chimeric. Since technical and ethical limitations make neurological disorders difficult to study in humans, chimeric models with human neural tissue could help advance our understanding of neuropathophysiology. In (...)
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  • Ethical Arguments Concerning Human-Animal Chimera Research: A Systematic Review.Koko Kwisda, Lucie White & Dietmar Hübner - 2020 - BMC Medical Ethics 21:1-14.
    The burgeoning field of biomedical research involving the mixture of human and animal materials has attracted significant ethical controversy. Due to the many dimensions of potential ethical conflict involved in this type of research, and the wide variety of research projects under discussion, it is difficult to obtain an overview of the ethical debate. This paper attempts to remedy this by providing a systematic review of ethical reasons in academic publications on human-animal chimera research. We conducted a systematic review of (...)
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  • Human-Animal Chimeras and Hybrids: An Ethical Paradox behind Moral Confusion?Dietmar Hübner - 2018 - Journal of Medicine and Philosophy 43 (2):187-210.
    The prospect of creating and using human–animal chimeras and hybrids that are significantly human-like in their composition, phenotype, cognition, or behavior meets with divergent moral judgments: on the one side, it is claimed that such beings might be candidates for human-analogous rights to protection and care; on the other side, it is supposed that their existence might disturb fundamental natural and social orders. This paper tries to show that both positions are paradoxically intertwined: they rely on two kinds of species (...)
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  • Ethical aspects of creating human–nonhuman chimeras capable of human gamete production and human pregnancy.César Palacios-González - 2015 - Monash Bioethics Review 33 (2-3):181-202.
    In this paper I explore some of the moral issues that could emerge from the creation of human–nonhuman chimeras capable of human gamete production and human pregnancy. First I explore whether there is a cogent argument against the creation of HNH-chimeras that could produce human gametes. I conclude that so far there is none, and that in fact there is at least one good moral reason for producing such types of creatures. Afterwards I explore some of the moral problems that (...)
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  • Harming animals for research and for food in conditions of moral uncertainty.Robert Streiffer - 2019 - Journal of Medical Ethics 45 (7):453-454.
    Koplin and Wilkinson (K&W) argue for the sociological claim that many believe (1) that the moral uncertainty argument provides significant moral reasons against farming human–pig chimaeras for their organs (henceforth, ‘farming for organs’) but (2) that there no are significant moral reasons against farming non-chimeric pigs for food (henceforth, ‘farming for food’). And yet, K&W argue for the ethical claim, that if the moral uncertainty argument provides significant moral reasons against farming for organs then there are similar moral reasons against (...)
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  • (2 other versions)Introduction.John A. Robertson - 2010 - Journal of Law, Medicine and Ethics 38 (2):175-190.
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  • Inductive Risks, Inferences, and the Role of Values in Disorders of Consciousness.Laura Y. Cabrera - 2016 - American Journal of Bioethics Neuroscience 7 (1):57-59.
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  • (2 other versions)Law, Science, and Innovation: Introduction to the Symposium.John A. Robertson - 2010 - Journal of Law, Medicine and Ethics 38 (2):175-190.
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  • Human–Animal Chimera: A Neuro Driven Discussion? Comparison of Three Leading European Research Countries.Laura Yenisa Cabrera Trujillo & Sabrina Engel-Glatter - 2015 - Science and Engineering Ethics 21 (3):595-617.
    Research with human–animal chimera raises a number of ethical concerns, especially when neural stem cells are transplanted into the brains of non-human primates . Besides animal welfare concerns and ethical issues associated with the use of embryonic stem cells, the research is also regarded as controversial from the standpoint of NHPs developing cognitive or behavioural capabilities that are regarded as “unique” to humans. However, scientists are urging to test new therapeutic approaches for neurological diseases in primate models as they better (...)
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  • Reframing the Ethical Issues in Part-Human Animal Research: The Unbearable Ontology of Inexorable Moral Confusion.Matthew H. Haber & Bryan Benham - 2012 - American Journal of Bioethics 12 (9):17-25.
    Research that involves the creation of animals with human-derived parts opens the door to potentially valuable scientific and therapeutic advances, yet invokes unsettling moral questions. Critics and champions alike stand to gain from clear identification and careful consideration of the strongest ethical objections to this research. A prevailing objection argues that crossing the human/nonhuman species boundary introduces inexorable moral confusion (IMC) that warrants a restriction to this research on precautionary grounds. Though this objection may capture the intuitions of many who (...)
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